| Literature DB >> 22572822 |
Qing Lin1, Li Wang, Youkun Lin, Xialin Liu, Xiangrong Ren, Sijian Wen, Xiaolin Du, Tao Lu, Sarah Y Su, Xiaoping Yang, Wenlin Huang, Shiyou Zhou, Feng Wen, Shao Bo Su.
Abstract
Toll-like receptors (TLRs) are pattern-recognition receptors and have a critical role in both innate and adaptive responses to tissue injury. Our previous study showed that wound healing was impaired in TLR3-deficient mice. In this study, we investigated the capacity of the TLR3 agonist polyriboinosinic-polyribocytidylic acid (poly(I:C)) to promote the healing of skin wounds in humans and mice. We found that topical application with poly(I:C) accelerated the closure of wounds in patients with laser plastic surgery. In a mouse model, topical application of poly(I:C) markedly enhanced re-epithelialization, granulation, and neovascularization required for wound closure. Further studies revealed that poly(I:C) treatment resulted in enhanced recruitment of neutrophils and macrophages in association with upregulation of a chemokine, macrophage inflammatory protein-2 (MIP-2/CXCL2), in the wounds. The effect of poly(I:C) was abolished in TLR3-deficient mice or by treatment with MIP-2/CXCL2-neutralizing antibodies. These results suggest a potential therapeutic value of the TLR3 activator poly(I:C) for wound healing.Entities:
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Year: 2012 PMID： 22572822 DOI： 10.1038/jid.2012.120
Source DB: PubMed Journal: J Invest Dermatol ISSN： 0022-202X Impact factor: 8.551