Literature DB >> 22572544

Macrophage differentiation and function in atherosclerosis: opportunities for therapeutic intervention?

Howell J Williams1, Edward A Fisher, David R Greaves.   

Abstract

The macrophage is exquisitely sensitive to its microenvironment, as demonstrated primarily through in vitro study. Changes in macrophage phenotype and function within the atherosclerotic plaque have profound consequences for plaque biology, including rupture and arterial thrombosis leading to clinical events such as myocardial infarction. We review the evidence for dynamic changes in macrophage numbers and macrophage differentiation within the atherosclerotic plaque microenvironment and discuss potential approaches to target macrophage differentiation for therapeutic benefit in cardiovascular disease.
Copyright © 2012 S. Karger AG, Basel.

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Year:  2012        PMID： 22572544      PMCID： PMC3598573          DOI： 10.1159/000336618

Source DB:  PubMed          Journal:  J Innate Immun        ISSN： 1662-811X            Impact factor:   7.349


  81 in total

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