Literature DB >> 22572505

ST-segment elevation and ventricular tachycardia after ingestion of a common ornamental plant-a case report.

Rami A Jambeih1, Wassim H Shaheen, Vuy Y Li, Mazen H Shaheen.   

Abstract

Japanese yew is a widely used ornamental plant. However, most people are unaware that it is also a poisonous plant. It has potent cardiac toxicities that can lead to sudden cardiac death. A 37-year-old female patient presented to the emergency room with altered mental status and sustained ventricular tachycardia (VT). Electrocardiogram (ECG) after cardioversion showed profound QRS prolongation and ST-segment elevation suggestive of either hyperkalaemia, acute myocardial ischaemia, or Brugada syndrome. Her electrolytes and coronary angiography were normal. After improvement of the patient's mental status, she admitted that she has been consuming Japanese yew from her yard for several months. Few hours later, QRS duration normalised, but mild ST-segment elevation persisted in the right pre-cordial leads, making it more suspicious for Brugada syndrome. However, a procainamide challenge test and electrophysiology study failed to induce typical Brugada pattern ECG and VT. The absence of coronary artery disease and electrolytes disturbances points toward the fact that her arrhythmia and ECG changes are secondary to yew intoxication. The patient was monitored for a few days. She was haemodynamically stable and has not had any arrhythmia. This case highlights the importance of public awareness of severe toxicity from Japanese yew or other yew plants. Yews contain taxines that are responsible for the ECG abnormalities due to its inhibitory effect on the cardiac sodium and calcium channels. They cause conduction abnormalities, VT, and ST-segment elevation that can resemble acute myocardial infarction, hyperkalaemia, and Brugada syndrome.
Copyright © 2012 Cardiological Society of India. Published by Elsevier B.V. All rights reserved.

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Year:  2012        PMID: 22572505      PMCID: PMC3861151          DOI: 10.1016/S0019-4832(12)60066-2

Source DB:  PubMed          Journal:  Indian Heart J        ISSN: 0019-4832


  6 in total

Review 1.  Taxines: a review of the mechanism and toxicity of yew (Taxus spp.) alkaloids.

Authors:  C R Wilson; J Sauer; S B Hooser
Journal:  Toxicon       Date:  2001 Feb-Mar       Impact factor: 3.033

2.  Images in cardiovascular medicine. Yew causes brugada ECG.

Authors:  Christian Veltmann; Martin Borggrefe; Rainer Schimpf; Christian Wolpert
Journal:  Circulation       Date:  2009-04-07       Impact factor: 29.690

3.  Role of sodium and calcium channel block in unmasking the Brugada syndrome.

Authors:  Jeffrey M Fish; Charles Antzelevitch
Journal:  Heart Rhythm       Date:  2004-07       Impact factor: 6.343

4.  Fatal cardiac arrhythmias and shock following yew leaves ingestion.

Authors:  B Yersin; J G Frey; M D Schaller; P Nicod; C Perret
Journal:  Ann Emerg Med       Date:  1987-12       Impact factor: 5.721

5.  Is the yew really poisonous to you?

Authors:  E P Krenzelok; T D Jacobsen; J Aronis
Journal:  J Toxicol Clin Toxicol       Date:  1998

Review 6.  Biological activity and chemistry of taxoids from the Japanese yew, Taxus cuspidata.

Authors:  Hideyuki Shigemori; Jun'ichi Kobayashi
Journal:  J Nat Prod       Date:  2004-02       Impact factor: 4.050

  6 in total

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