AIMS AND OBJECTIVES: Pregnancy associated plasma protein-A (PAPP-A), a metalloproteinase plays a pivotal role in the pathogenesis of atherosclerosis. Recent studies have reported that elevated levels of PAPP-A, signal the onset of acute coronary syndrome (ACS). We, therefore, proposed to study the analytical competence of PAPP-A in patients admitted to the emergency department with chest pain and finally diagnosed as ACS. METHODS AND RESULTS: Pregnancy associated plasma protein-A was measured using enzyme-linked immunosorbent assay (ELISA) in 485 patients admitted to emergency care unit, of which 89 patients were diagnosed as Non-cardiac chest pain (NCCP). Elevated levels of PAPP-A were observed in patients diagnosed as ACS on comparison with the controls. Receiver operator characteristic (ROC) curve analysis showed PAPP-A to be a good discriminator between ischaemic and non-ischaemic patients. The area under the curve was found to be 0.904, 95% CI (0.874-0.929) with 90% sensitivity and 85% specificity (P< 0.0001). The cut-off value from the ROC curve was 0.55 μg/mL above which PAPP-A was considered to be positive. CONCLUSION: Pregnancy associated plasma protein-A seems to be a promising biomarker for identification and risk stratification for patients with ACS.
AIMS AND OBJECTIVES:Pregnancy associated plasma protein-A (PAPP-A), a metalloproteinase plays a pivotal role in the pathogenesis of atherosclerosis. Recent studies have reported that elevated levels of PAPP-A, signal the onset of acute coronary syndrome (ACS). We, therefore, proposed to study the analytical competence of PAPP-A in patients admitted to the emergency department with chest pain and finally diagnosed as ACS. METHODS AND RESULTS:Pregnancy associated plasma protein-A was measured using enzyme-linked immunosorbent assay (ELISA) in 485 patients admitted to emergency care unit, of which 89 patients were diagnosed as Non-cardiac chest pain (NCCP). Elevated levels of PAPP-A were observed in patients diagnosed as ACS on comparison with the controls. Receiver operator characteristic (ROC) curve analysis showed PAPP-A to be a good discriminator between ischaemic and non-ischaemic patients. The area under the curve was found to be 0.904, 95% CI (0.874-0.929) with 90% sensitivity and 85% specificity (P< 0.0001). The cut-off value from the ROC curve was 0.55 μg/mL above which PAPP-A was considered to be positive. CONCLUSION:Pregnancy associated plasma protein-A seems to be a promising biomarker for identification and risk stratification for patients with ACS.
Authors: A Bayes-Genis; R S Schwartz; D A Lewis; M T Overgaard; M Christiansen; C Oxvig; K Ashai; D R Holmes; C A Conover Journal: Arterioscler Thromb Vasc Biol Date: 2001-03 Impact factor: 8.311
Authors: Christopher Heeschen; Stefanie Dimmeler; Christian W Hamm; Stephan Fichtlscherer; Maarten L Simoons; Andreas M Zeiher Journal: J Am Coll Cardiol Date: 2005-01-18 Impact factor: 24.094
Authors: Ahmad A Elesber; Cheryl A Conover; Ali E Denktas; Ryan J Lennon; David R Holmes; Michael T Overgaard; Michael Christiansen; Claus Oxvig; Lilach O Lerman; Amir Lerman Journal: Eur Heart J Date: 2006-05-22 Impact factor: 29.983
Authors: A Bayes-Genis; C A Conover; M T Overgaard; K R Bailey; M Christiansen; D R Holmes; R Virmani; C Oxvig; R S Schwartz Journal: N Engl J Med Date: 2001-10-04 Impact factor: 91.245