Literature DB >> 22571894

Plasma profiles of glucose, insulin and lipids in the male WBN/Kob-Lepr(fa) rat, a new model of type 2 diabetes with obesity.

Noriyuki Kaji1, Akira Okuno, Kanako Ohno-Ichiki, Hisako Oki, Haruya Ishizawa, Mitsuyuki Shirai, Fumitoshi Asai.   

Abstract

Plasma profiles of glucose, insulin and lipids were examined in the male WBN/Kob-Lepr(fa) (fa/fa) rat, a new model of type 2 diabetes (T2D), in comparison with age-matched original male WBN/Kob (lean) rats. The fa/fa rats developed hypertriglycemia, obesity and hyperglycemia from 5, 7, and 9 weeks of age, respectively. Plasma insulin levels in fa/fa rats were significantly higher than those in lean rats at 5 weeks of age, but after 11 weeks of age gradually declined to the levels in lean rats. HOMA-IR, a measure of insulin resistance status, showed that fa/fa rats had insulin resistance. The fa/fa rat has the potential to become an important animal model of T2D with obesity.

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Year:  2012        PMID： 22571894     DOI： 10.1292/jvms.12-0045

Source DB:  PubMed          Journal:  J Vet Med Sci        ISSN： 0916-7250            Impact factor:   1.267


  10 in total

1.  Prophylactic effects of the glucagon-like Peptide-1 analog liraglutide on hyperglycemia in a rat model of type 2 diabetes mellitus associated with chronic pancreatitis and obesity.

Authors:  Dai Nagakubo; Mitsuyuki Shirai; Yuki Nakamura; Noriyuki Kaji; Chika Arisato; Sena Watanabe; Ayami Takasugi; Fumitoshi Asai
Journal:  Comp Med       Date:  2014-04       Impact factor: 0.982

2.  Effects of high-sodium intake on systemic blood pressure and vascular responses in spontaneously diabetic WBN/Kob-Leprfa/fa rats.

Authors:  Yoshiichi Takagi; Haruno Kadowaki; Ikumi Kobayashi; Kaoru Ito; Katsuaki Ito; Mitsuyuki Shirai; Fumitoshi Asai
Journal:  Clin Exp Pharmacol Physiol       Date:  2017-02       Impact factor: 2.557

3.  Effects of high-fat diet and fructose-rich diet on obesity, dyslipidemia and hyperglycemia in the WBN/Kob-Leprfa rat, a new model of type 2 diabetes mellitus.

Authors:  Junichi Namekawa; Yoshiichi Takagi; Kaoru Wakabayashi; Yuki Nakamura; Ayaka Watanabe; Dai Nagakubo; Mitsuyuki Shirai; Fumitoshi Asai
Journal:  J Vet Med Sci       Date:  2017-04-21       Impact factor: 1.267

Review 4.  Relationship between Immunological Abnormalities in Rat Models of Diabetes Mellitus and the Amplification Circuits for Diabetes.

Authors:  Yuji Takeda; Tomoko Shimomura; Hironobu Asao; Ichiro Wakabayashi
Journal:  J Diabetes Res       Date:  2017-02-19       Impact factor: 4.011

5.  Characteristics of WBN/Kob diabetic fatty rats supplemented with a fructose-rich diet as a metabolic syndrome model: response to a GLP-1 receptor agonist.

Authors:  Junichi Namekawa; Sayaka Nemoto; Gaku Sunada; Yuki Takanashi; Sakurako Fujio; Mitsuyuki Shirai; Fumitoshi Asai
Journal:  J Vet Med Sci       Date:  2018-08-31       Impact factor: 1.267

6.  Effects of liraglutide on metabolic syndrome in WBN/Kob diabetic fatty rats supplemented with a high-fat diet.

Authors:  Noriyuki Kaji; Yoshiichi Takagi; Satomi Matsuda; Anna Takahashi; Sakurako Fujio; Fumitoshi Asai
Journal:  Animal Model Exp Med       Date:  2020-03-16

7.  Role of insulin resistance in the pathogenesis and development of type 2 diabetes in WBN/Kob-Lepr(fa) rats.

Authors:  Akira Okuno; Noriyuki Kaji; Atsushi Takahashi; Dai Nagakubo; Kanako Ohno-Ichiki; Mitsuyuki Shirai; Fumitoshi Asai
Journal:  J Vet Med Sci       Date:  2013-07-26       Impact factor: 1.267

8.  High-Salt Intake Ameliorates Hyperglycemia and Insulin Resistance in WBN/Kob-Leprfa/fa Rats: A New Model of Type 2 Diabetes Mellitus.

Authors:  Yoshiichi Takagi; Taichi Sugimoto; Masaya Kobayashi; Mitsuyuki Shirai; Fumitoshi Asai
Journal:  J Diabetes Res       Date:  2018-03-20       Impact factor: 4.011

9.  Teriparatide Improves Bone and Lipid Metabolism in a Male Rat Model of Type 2 Diabetes Mellitus.

Authors:  Sachiko Nomura; Akihiro Kitami; Ryoko Takao-Kawabata; Aya Takakura; Momoko Nakatsugawa; Ryohei Kono; Akihiro Maeno; Akihiko Tokuda; Yukihiro Isogai; Toshinori Ishizuya; Hirotoshi Utsunomiya; Misa Nakamura
Journal:  Endocrinology       Date:  2019-10-01       Impact factor: 4.736

10.  High IL-1α Production Was Induced in the WBN/Kob-Leprfa Type 2 Diabetes Mellitus Rat Model and Inhibited by Syphacia Muris Infection.

Authors:  M Okamoto; R Ito; K Taira; T Ikeda
Journal:  Helminthologia       Date:  2018-01-27       Impact factor: 1.184
  10 in total

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