Literature DB >> 22571369

Blocking interleukin-1 as a novel therapeutic strategy for secondary prevention of cardiovascular events.

Antonio Abbate1, Benjamin W Van Tassell, Giuseppe G L Biondi-Zoccai.   

Abstract

The inflammatory hypothesis of atherosclerosis postulates that inflammation within the plaque promotes plaque progression and complications. Interleukin-1 (IL-1) is a key pro-inflammatory cytokine responsible for the amplification of the inflammatory response following injury. Animal studies show that IL-1 blockade is effective in limiting atherosclerosis and atherothrombosis and improving outcomes in acute myocardial infarction and ischemic stroke. Preliminary data in patients with acute myocardial infarction, ischemic stroke, and heart failure are promising. A large secondary prevention trial with canakinumab in patients with prior acute myocardial infarction is currently ongoing. Many unanswered questions remain regarding the optimal use of IL-1 blockade and the preferred agent.

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Year:  2012        PMID： 22571369     DOI： 10.1007/bf03261881

Source DB:  PubMed          Journal:  BioDrugs        ISSN： 1173-8804            Impact factor:   5.807


  28 in total

Review 1.  Interleukin-1 Beta as a Target for Atherosclerosis Therapy: Biological Basis of CANTOS and Beyond.

Authors:  Peter Libby
Journal:  J Am Coll Cardiol       Date:  2017-10-31       Impact factor: 24.094

Review 2.  Atherothrombosis Prevention and Treatment with Anti-interleukin-1 Agents.

Authors:  Giuseppe Biondi-Zoccai; Cristian M Garmendia; Antonio Abbate; Arturo Giordano; Giacomo Frati; Sebastiano Sciarretta; Barbara Antonazzo; Francesco Versaci
Journal:  Curr Atheroscler Rep       Date:  2020-01-13       Impact factor: 5.113

Review 3.  Therapeutics targeting the inflammasome after central nervous system injury.

Authors:  Juan Pablo de Rivero Vaccari; W Dalton Dietrich; Robert W Keane
Journal:  Transl Res       Date:  2015-05-12       Impact factor: 7.012

4.  Rationale and design of the Virginia Commonwealth University-Anakinra Remodeling Trial-3 (VCU-ART3): A randomized, placebo-controlled, double-blinded, multicenter study.

Authors:  Benjamin W Van Tassell; Michael J Lipinski; Darryn Appleton; Charlotte S Roberts; Michael C Kontos; Nayef Abouzaki; Ryan Melchior; George Mueller; James Garnett; Justin Canada; Salvatore Carbone; Leo F Buckley; George Wohlford; Dinesh Kadariya; Cory R Trankle; Claudia Oddi Erdle; Robin Sculthorpe; Laura Puckett; Christine DeWilde; Keyur Shah; Dominick J Angiolillo; George Vetrovec; Giuseppe Biondi-Zoccai; Ross Arena; Antonio Abbate
Journal:  Clin Cardiol       Date:  2018-08-17       Impact factor: 2.882

Review 5.  Apical Periodontitis - Is It Accountable for Cardiovascular Diseases?

Authors:  Paridhi Garg; Chandrakar Chaman
Journal:  J Clin Diagn Res       Date:  2016-08-01

6.  N,N-dimethylacetamide regulates the proinflammatory response associated with endotoxin and prevents preterm birth.

Authors:  Sruthi Sundaram; Charles R Ashby; Ryan Pekson; Vaishali Sampat; Ravikumar Sitapara; Lin Mantell; Chih-Hung Chen; Haoting Yen; Khushboo Abhichandani; Swapna Munnangi; Nikhil Khadtare; Ralph A Stephani; Sandra E Reznik
Journal:  Am J Pathol       Date:  2013-06-12       Impact factor: 4.307

7.  Cyclovirobuxinum D suppresses lipopolysaccharide-induced inflammatory responses in murine macrophages in vitro by blocking JAK-STAT signaling pathway.

Authors:  Dan Guo; Jing-Rong Li; Ying Wang; Lin-Sheng Lei; Chuan-Lin Yu; Na-Na Chen
Journal:  Acta Pharmacol Sin       Date:  2014-04-21       Impact factor: 6.150

Review 8.  Targeting interleukin-1 in heart disease.

Authors:  Benjamin W Van Tassell; Stefano Toldo; Eleonora Mezzaroma; Antonio Abbate
Journal:  Circulation       Date:  2013-10-22       Impact factor: 29.690

9.  Induction of microRNA-21 with exogenous hydrogen sulfide attenuates myocardial ischemic and inflammatory injury in mice.

Authors:  Stefano Toldo; Anindita Das; Eleonora Mezzaroma; Vinh Q Chau; Carlo Marchetti; David Durrant; Arun Samidurai; Benjamin W Van Tassell; Chang Yin; Ramzi A Ockaili; Navin Vigneshwar; Nitai D Mukhopadhyay; Rakesh C Kukreja; Antonio Abbate; Fadi N Salloum
Journal:  Circ Cardiovasc Genet       Date:  2014-05-13

10.  Interleukin-18 mediates interleukin-1-induced cardiac dysfunction.

Authors:  Stefano Toldo; Eleonora Mezzaroma; Laura O'Brien; Carlo Marchetti; Ignacio M Seropian; Norbert F Voelkel; Benjamin W Van Tassell; Charles A Dinarello; Antonio Abbate
Journal:  Am J Physiol Heart Circ Physiol       Date:  2014-02-14       Impact factor: 4.733
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