BACKGROUND: This RCT compared non-surgical treatment of peri-implant mucositis with or without systemic antibiotics. MATERIALS AND METHODS:Forty-eight subjects receivednon-surgical debridement with or without systemic Azithromax (®) (4 days), and were followed during 6 months. The checkerboard DNA-DNA hybridization method was used to analyse the microbiological material. RESULTS:Five subjects were excluded due to antibiotic medication during follow-up. At baseline,1 and 3 months no group differences were found. Statistical analysis failed to demonstrate differences in probing pocket depths (PPD) values at 6 months (Mean diff PPD: 0.5 mm, SE: ±0.4 mm, 95% CI: -0.2, 1.3, p = 0.16). Mean% implant bleeding decreased between baseline and month 6 from 82.6% to 27.3% in the test, and from 80.0% to 47.5% in the control group (p < 0.02). Throughout the study, no study group differences in bacterial counts were found. CONCLUSION: No short-term differences were found between study groups. The clinical improvements observed at 6 months may be attributed to improvements in oral hygiene. The present study does not provide evidence for the use of systemic antibiotics in treatment of peri-implant mucositis.
RCT Entities:
BACKGROUND: This RCT compared non-surgical treatment of peri-implant mucositis with or without systemic antibiotics. MATERIALS AND METHODS: Forty-eight subjects received non-surgical debridement with or without systemic Azithromax (®) (4 days), and were followed during 6 months. The checkerboard DNA-DNA hybridization method was used to analyse the microbiological material. RESULTS: Five subjects were excluded due to antibiotic medication during follow-up. At baseline,1 and 3 months no group differences were found. Statistical analysis failed to demonstrate differences in probing pocket depths (PPD) values at 6 months (Mean diff PPD: 0.5 mm, SE: ±0.4 mm, 95% CI: -0.2, 1.3, p = 0.16). Mean% implant bleeding decreased between baseline and month 6 from 82.6% to 27.3% in the test, and from 80.0% to 47.5% in the control group (p < 0.02). Throughout the study, no study group differences in bacterial counts were found. CONCLUSION: No short-term differences were found between study groups. The clinical improvements observed at 6 months may be attributed to improvements in oral hygiene. The present study does not provide evidence for the use of systemic antibiotics in treatment of peri-implant mucositis.
Authors: Tassiane Panta Wagner; Paula Rodrigues Pires; Fernando Silva Rios; Joao Augusto Peixoto de Oliveira; Ricardo Dos Santos Araujo Costa; Kelly F Cunha; Heraldo Luis Dias Silveira; Suzana Pimentel; Marcio Zaffalon Casati; Cassiano Kuchenbecker Rosing; Alex Nogueira Haas Journal: Clin Oral Investig Date: 2021-03-16 Impact factor: 3.573
Authors: Manuel Toledano-Osorio; Cristina Vallecillo; Raquel Toledano; Fátima S Aguilera; María T Osorio; Esther Muñoz-Soto; Franklin García-Godoy; Marta Vallecillo-Rivas Journal: Int J Environ Res Public Health Date: 2022-05-26 Impact factor: 4.614
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