BACKGROUND/ OBJECTIVES: Extremes of birthweight (BW) have been associated with increased rates of metabolic risks. The objective was to study the prevalence of metabolic risks markers among obese and overweight (OW) subjects according to BW. SUBJECTS/ METHODS: A cross-sectional study was performed in a cohort of 1002 patients (2-18 years, 40.6% male) evaluated for OW or obese subjects in two private clinics. Anthropometrics, fasting lipids, glycemia, and insulin were obtained. RESULTS: Of the subjects, 76.1% were born appropriate for gestational age (AGA), 10.9% small for gestational age (SGA), and 13% large for gestational age (LGA). Children born LGA presented a more severe degree of obesity compared with those born AGA and SGA (p<0.0001). No differences in glycemia, insulin, and lipid levels were detected among the groups. Abnormal glucose was found in 37 subjects: one with type 2 diabetes mellitus (from the previously glucose-intolerant subjects), 10 with glucose intolerance, and 27 with impaired fasting glucose. According to Boney criteria, 6.6% of the patients (6-18 years old) exhibited metabolic syndrome (MS) (69.4% AGA, 12.9% SGA, and 17.7% LGA). CONCLUSIONS: Being born LGA represents a higher risk of severe obesity. At this age, the most frequent component of MS was an abnormal lipid profile with low high-density lipoprotein and high triglycerides. Finally, the most frequent finding associated with abnormalities of glucose tolerance was a family history of diabetes. Thus, BW, lipid profile, and family history are mandatory when these patients are evaluated.
BACKGROUND/ OBJECTIVES: Extremes of birthweight (BW) have been associated with increased rates of metabolic risks. The objective was to study the prevalence of metabolic risks markers among obese and overweight (OW) subjects according to BW. SUBJECTS/ METHODS: A cross-sectional study was performed in a cohort of 1002 patients (2-18 years, 40.6% male) evaluated for OW or obese subjects in two private clinics. Anthropometrics, fasting lipids, glycemia, and insulin were obtained. RESULTS: Of the subjects, 76.1% were born appropriate for gestational age (AGA), 10.9% small for gestational age (SGA), and 13% large for gestational age (LGA). Children born LGA presented a more severe degree of obesity compared with those born AGA and SGA (p<0.0001). No differences in glycemia, insulin, and lipid levels were detected among the groups. Abnormal glucose was found in 37 subjects: one with type 2 diabetes mellitus (from the previously glucose-intolerant subjects), 10 with glucose intolerance, and 27 with impaired fasting glucose. According to Boney criteria, 6.6% of the patients (6-18 years old) exhibited metabolic syndrome (MS) (69.4% AGA, 12.9% SGA, and 17.7% LGA). CONCLUSIONS: Being born LGA represents a higher risk of severe obesity. At this age, the most frequent component of MS was an abnormal lipid profile with low high-density lipoprotein and high triglycerides. Finally, the most frequent finding associated with abnormalities of glucose tolerance was a family history of diabetes. Thus, BW, lipid profile, and family history are mandatory when these patients are evaluated.
Authors: Vanessa M Oddo; Noel T Mueller; Keshia M Pollack; Pamela J Surkan; Sara N Bleich; Jessica C Jones-Smith Journal: Public Health Nutr Date: 2017-08-04 Impact factor: 4.022
Authors: Barbara Luke; Morton B Brown; Ethan Wantman; Judy E Stern; James P Toner; Charles C Coddington Journal: J Assist Reprod Genet Date: 2016-12-01 Impact factor: 3.412
Authors: Caroline Ponzio; Zaira Palomino; Rosana Fiorini Puccini; Maria Wany L Strufaldi; Maria C P Franco Journal: Eur J Pediatr Date: 2013-08-03 Impact factor: 3.183
Authors: Francisco Mardones; Pilar Arnaiz; Paz Pacheco; Angelica Dominguez; Luis Villarroel; Johan G Eriksson; Salesa Barja; Marcelo Farías; Oscar Castillo Journal: Biomed Res Int Date: 2014-06-15 Impact factor: 3.411