| Literature DB >> 2257061 |
A Nordberg1, P Hartvig, A Lilja, M Viitanen, K Amberla, H Lundqvist, Y Andersson, J Ulin, B Winblad, B Långström.
Abstract
Positron emission tomography of the brain following intravenous injection of (+) (R) and (-) (S) N-[11C-methyl]nicotine showed a marked reduced uptake of both isomers, especially the (R) form, in Alzheimer patients as compared to age-matched controls. The significantly larger difference between the uptake values of the (S)- and (R)-enantiomers of 11C-nicotine in Azheimer brains may be of diagnostic value.Entities:
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Year: 1990 PMID： 2257061 DOI： 10.1007/bf02257652
Source DB: PubMed Journal: J Neural Transm Park Dis Dement Sect ISSN： 0936-3076