Literature DB >> 22570249

Complete genome sequence of an overattenuated highly pathogenic porcine reproductive and respiratory syndrome virus.

Jiajun Wu1, Nanhua Chen, Wei Han, Zhen Cao, Xiaoyu Deng, Lilin Wang, Xiuling Yu, Zhi Zhou, Xiangdong Li, Jishu Shi, Kegong Tian.   

Abstract

JXA1-P170 is an overattenuated highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) that has been passaged in vitro 170 times. Vaccination with JXA1-P170 cannot protect pigs against JXA1 challenge. Compared with the parental virus JXA1, JXA1-P170 contains 1 nucleotide (nt) deletion and 113 nt mutations leading to 59 amino acid substitutions. Here we announce the first complete genome sequence of the overattenuated HP-PRRSV.

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Year:  2012        PMID： 22570249      PMCID： PMC3372184          DOI： 10.1128/JVI.00710-12

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


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