Literature DB >> 22569356

Aging and dry eye disease.

Juan Ding1, David A Sullivan.   

Abstract

Dry eye disease is a prevalent eye disorder that in particular affects the elderly population. One of the major causes of dry eye, meibomian gland dysfunction (MGD), shows increased prevalence with aging. MGD is caused by hyperkeratinization of the ductal epithelium of meibomian gland and reduced quantity and/or quality of meibum, the holocrine product that stabilizes and prevents the evaporation of the tear film. Of note, retinoids which are used in current anti-aging cosmetics may promote the development of MGD and dry eye disease. In this review, we will discuss the possible mechanisms of age-related MGD.
Copyright © 2012 Elsevier Inc. All rights reserved.

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Year:  2012        PMID： 22569356      PMCID： PMC3368077          DOI： 10.1016/j.exger.2012.03.020

Source DB:  PubMed          Journal:  Exp Gerontol        ISSN： 0531-5565            Impact factor:   4.032


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