| Literature DB >> 22569338 |
Cory L Howk1, Howard A Levine, Michael W Smiley, Surya K Mallapragada, Marit Nilsen-Hamilton, Jisun Oh, Donald S Sakaguchi.
Abstract
The biological hypothesis that the astrocyte-secreted cytokine, interleukin-6 (IL6), stimulates differentiation of adult rat hippocampal progenitor cells (AHPCs) is considered from a mathematical perspective. The proposed mathematical model includes two different mechanisms for stimulation and is based on mass-action kinetics. Both biological mechanisms involve sequential binding, with one pathway solely utilizing surface receptors while the other pathway also involves soluble receptors. Choosing biologically-reasonable values for parameters, simulations of the mathematical model show good agreement with experimental results. A global sensitivity analysis is also conducted to determine both the most influential and non-influential parameters on cellular differentiation, providing additional insights into the biological mechanisms.Entities:
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Year: 2012 PMID： 22569338 PMCID： PMC3413252 DOI： 10.1016/j.mbs.2012.04.001
Source DB: PubMed Journal: Math Biosci ISSN： 0025-5564 Impact factor: 2.144