| Literature DB >> 22569043 |
Yongqian Bian1, Li Wang, Huanyu Lu, Guodong Yang, Zhang Zhang, Haiyan Fu, Xiaozhao Lu, Mengying Wei, Jianyong Sun, Qingchuan Zhao, Guanglong Dong, Zifan Lu.
Abstract
Gastric cancer (GC) is the fourth most common cancer and second leading cause of cancer-related death worldwide. RNA-binding protein Quaking (QKI) is a newly identified tumor suppressor in multiple cancers, while its role in GC is largely unknown. Our study here aimed to clarify the relationship between QKI expression with the clinicopathologic characteristics and the prognosis of GC. In the 222 GC patients' specimens, QKI expression was found to be significantly decreased in most of the GC tissues, which was largely due to promoter hypermethylation. QKI overexpression reduced the proliferation ability of GC cell line in vitro study. In addition, the reduced QKI expression correlated well with poor differentiation status, depth of invasion, gastric lymph node metastasis, distant metastasis, advanced TNM stage, and poor survival. Multivariate analysis showed QKI expression was an independent prognostic factor for patient survival.Entities:
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Year: 2012 PMID： 22569043 DOI： 10.1016/j.bbrc.2012.04.138
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575