Literature DB >> 22568898

Enhanced antiviral activity of acyclovir loaded into nanoparticles.

Roberta Cavalli1, Manuela Donalisio, Agnese Bisazza, Andrea Civra, Elisabetta Ranucci, Paolo Ferruti, David Lembo.   

Abstract

The activity of antivirals can be enhanced by their incorporation in nanoparticulate delivery systems. Peculiar polymeric nanoparticles, based on a β-cyclodextrin-poly(4-acryloylmorpholine) monoconjugate (β-CD-PACM), are proposed as acyclovir carriers. The experimental procedure necessary to obtain the acyclovir-loaded nanoparticles using the solvent displacement preparation method will be described in this chapter. Fluorescent labeled nanoparticles are prepared using the same method for cellular trafficking studies. The biocompatibility assays necessary to obtain safe nanoparticles are reported. Section 4 of this chapter describes the assessment of the antiviral activity of the acyclovir-loaded nanoparticles.
Copyright © 2012 Elsevier Inc. All rights reserved.

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Year:  2012        PMID： 22568898     DOI： 10.1016/B978-0-12-391858-1.00001-0

Source DB:  PubMed          Journal:  Methods Enzymol        ISSN： 0076-6879            Impact factor:   1.600


  8 in total

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3.  Grape Canes from Typical Cultivars of Campania (Southern Italy) as a Source of High-Value Bioactive Compounds: Phenolic Profile, Antioxidant and Antimicrobial Activities.

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4.  M48U1 and Tenofovir combination synergistically inhibits HIV infection in activated PBMCs and human cervicovaginal histocultures.

Authors:  Giuseppina Musumeci; Isabella Bon; David Lembo; Valeria Cagno; Maria Carla Re; Caterina Signoretto; Erica Diani; Lucia Lopalco; Claudia Pastori; Loïc Martin; Gilles Ponchel; Davide Gibellini; Kawthar Bouchemal
Journal:  Sci Rep       Date:  2017-02-01       Impact factor: 4.379

Review 5.  Advanced Prodrug Strategies in Nucleoside and Non-Nucleoside Antiviral Agents: A Review of the Recent Five Years.

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6.  Cyclodextrin-based nanosponges as drug carriers.

Authors:  Francesco Trotta; Marco Zanetti; Roberta Cavalli
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7.  In vitro anti-Herpes simplex virus activity of crude extract of the roots of Nauclea latifolia Smith (Rubiaceae).

Authors:  Manuela Donalisio; Huguette Magnifouet Nana; Rosalie Annie Ngono Ngane; Donatien Gatsing; Alembert Tiabou Tchinda; Roberta Rovito; Valeria Cagno; Cecilia Cagliero; Fabrice Fekam Boyom; Patrizia Rubiolo; Carlo Bicchi; David Lembo
Journal:  BMC Complement Altern Med       Date:  2013-10-16       Impact factor: 3.659

8.  Acyclovir-Loaded Chitosan Nanospheres from Nano-Emulsion Templating for the Topical Treatment of Herpesviruses Infections.

Authors:  Manuela Donalisio; Federica Leone; Andrea Civra; Rita Spagnolo; Ozgen Ozer; David Lembo; Roberta Cavalli
Journal:  Pharmaceutics       Date:  2018-04-10       Impact factor: 6.321
  8 in total

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