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Literature DB >> 2256889

Mixed-model segregation analysis of schizophrenia in the Lindelius Swedish pedigrees.

G P Vogler¹, I I Gottesman, M K McGue, D C Rao.

Abstract

To test if familial transmission of schizophrenia is consistent with a model of monogenic inheritance with a multifactorial background, a mixed-model segregation analysis was applied to Swedish pedigrees consisting of 270 probands in 263 nuclear families. Results of the best-fitting mixed-model solutions are consistent with multifactorial transmission and no major gene. However, numerical instabilities prevented formal hypothesis testing, so an irrefutable genetic mechanism remains unidentified. Alternative research strategies that exploit recent advances in molecular genetics are discussed.

Entities: Disease

Mesh：

Year: 1990 PMID： 2256889 DOI： 10.1007/bf01067712

Source DB: PubMed Journal: Behav Genet ISSN： 0001-8244 Impact factor: 2.805

34 in total

1. Evidence against linkage of schizophrenia to markers on chromosome 5 in a northern Swedish pedigree.

Authors: J L Kennedy; L A Giuffra; H W Moises; L L Cavalli-Sforza; A J Pakstis; J R Kidd; C M Castiglione; B Sjogren; L Wetterberg; K K Kidd
Journal: Nature Date: 1988-11-10 Impact factor: 49.962

2. Localization of a susceptibility locus for schizophrenia on chromosome 5.

Authors: R Sherrington; J Brynjolfsson; H Petursson; M Potter; K Dudleston; B Barraclough; J Wasmuth; M Dobbs; H Gurling
Journal: Nature Date: 1988-11-10 Impact factor: 49.962

3. The genetical analysis of covariance structure.

Authors: N G Martin; L J Eaves
Journal: Heredity (Edinb) Date: 1977-02 Impact factor: 3.821

4. A general model for the genetic analysis of pedigree data.

Authors: R C Elston; J Stewart
Journal: Hum Hered Date: 1971 Impact factor: 0.444

Review 5. Candidate genes and favoured loci: strategies for molecular genetic research into schizophrenia, manic depression, autism, alcoholism and Alzheimer's disease.

Authors: H Gurling
Journal: Psychiatr Dev Date: 1986

6. Cerebral ventricular size in twins discordant for schizophrenia.

Authors: A M Reveley; M A Reveley; C A Clifford; R M Murray
Journal: Lancet Date: 1982-03-06 Impact factor: 79.321

7. Segregation analysis of schizophrenia under a mixed genetic model.

Authors: C L Carter; C S Chung
Journal: Hum Hered Date: 1980 Impact factor: 0.444

8. Research diagnostic criteria: rationale and reliability.

Authors: R L Spitzer; J Endicott; E Robins
Journal: Arch Gen Psychiatry Date: 1978-06

9. Refutation of the general single-locus model for the etiology of schizophrenia.

Authors: D H O'Rourke; I I Gottesman; B K Suarez; J Rice; T Reich
Journal: Am J Hum Genet Date: 1982-07 Impact factor: 11.025

10. Segregation analysis of schizophrenia and related disorders.

Authors: N Risch; M Baron
Journal: Am J Hum Genet Date: 1984-09 Impact factor: 11.025

10 in total

1. Both inherited susceptibility and environmental exposure determine the low-density lipoprotein-subfraction pattern distribution in healthy Dutch families.

Authors: J de Graaf; D W Swinkels; A F de Haan; P N Demacker; A F Stalenhoef
Journal: Am J Hum Genet Date: 1992-12 Impact factor: 11.025

2. Heritability of schizophrenia and major affective disorder as a function of age, in the presence of strong cohort effects.

Authors: Janice A Husted; Celia M T Greenwood; Anne S Bassett
Journal: Eur Arch Psychiatry Clin Neurosci Date: 2005-12-05 Impact factor: 5.270

Mixed-model segregation analysis of schizophrenia in the Lindelius Swedish pedigrees.

1. Evidence against linkage of schizophrenia to markers on chromosome 5 in a northern Swedish pedigree.

2. Localization of a susceptibility locus for schizophrenia on chromosome 5.

3. The genetical analysis of covariance structure.

4. A general model for the genetic analysis of pedigree data.

Review 5. Candidate genes and favoured loci: strategies for molecular genetic research into schizophrenia, manic depression, autism, alcoholism and Alzheimer's disease.

6. Cerebral ventricular size in twins discordant for schizophrenia.

7. Segregation analysis of schizophrenia under a mixed genetic model.

8. Research diagnostic criteria: rationale and reliability.

9. Refutation of the general single-locus model for the etiology of schizophrenia.

10. Segregation analysis of schizophrenia and related disorders.

1. Both inherited susceptibility and environmental exposure determine the low-density lipoprotein-subfraction pattern distribution in healthy Dutch families.

2. Heritability of schizophrenia and major affective disorder as a function of age, in the presence of strong cohort effects.

Review 3. The genetic epidemiology of schizophrenia and the design of linkage studies.

4. Anticipation or ascertainment bias in schizophrenia? Penrose's familial mental illness sample.

Review 5. The molecular genetics of schizophrenia.

6. A joint history of the nature of genetic variation and the nature of schizophrenia.

7. Complex segregation analysis of autism.

8. Elevated rates of schizophrenia in a familial sample with mental illness and intellectual disability.

9. Genetic liability to schizophrenia in Oceanic Palau: a search in the affected and maternal generation.

10. Toward a modern search for schizophrenia genes.