Literature DB >> 2256443

Pharmacokinetic comparison of two carbamazepine slow-release formulations.

P K Jensen1, A Møller, L Gram, N O Jensen, M Dam.   

Abstract

In a single-blind pharmacokinetic study patients being treated with conventional carbamazepine (CBZ) in a t.i.d. regimen were randomly allocated to identical doses of two CBZ slow-release formulations (Trimonil Retard and Tegretol Retard) administered once daily. Statistical analysis involved the following parameters: AUC, Cmin, Cmax and Fluctuation Index (FI). With regard to Cmin and FI statistically significant differences in favour of Tegretol Retard were observed.

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Year:  1990        PMID: 2256443     DOI: 10.1111/j.1600-0404.1990.tb01603.x

Source DB:  PubMed          Journal:  Acta Neurol Scand        ISSN: 0001-6314            Impact factor:   3.209


  5 in total

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Authors:  Alaa Ahmad; William R Garnett
Journal:  Clin Drug Investig       Date:  2005       Impact factor: 2.859

Review 2.  Pharmacokinetic evaluation of sustained release formulations of antiepileptic drugs. Clinical implications.

Authors:  M Bialer
Journal:  Clin Pharmacokinet       Date:  1992-01       Impact factor: 6.447

3.  Double dummy comparison between once and twice daily dosing with modified-release carbamazepine in epileptic patients.

Authors:  P J McKee; J Blacklaw; A Carswell; R A Gillham; M J Brodie
Journal:  Br J Clin Pharmacol       Date:  1993-09       Impact factor: 4.335

4.  USL255 extended-release topiramate: dose-proportional pharmacokinetics and tolerability in healthy volunteers.

Authors:  Annie M Clark; Mark B Halvorsen; Tricia L Braun; Krista M Johnson; James C Cloyd
Journal:  Epilepsia       Date:  2014-05-23       Impact factor: 5.864

Review 5.  Immediate-release versus controlled-release carbamazepine in the treatment of epilepsy.

Authors:  Graham Powell; Matthew Saunders; Alexandra Rigby; Anthony G Marson
Journal:  Cochrane Database Syst Rev       Date:  2016-12-08
  5 in total

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