Literature DB >> 22564250

Viral disruption of the blood-brain barrier.

Katherine R Spindler1, Tien-Huei Hsu.   

Abstract

The blood-brain barrier (BBB) provides significant protection against microbial invasion of the brain. However, the BBB is not impenetrable, and mechanisms by which viruses breach it are becoming clearer. In vivo and in vitro model systems are enabling identification of host and viral factors contributing to breakdown of the unique BBB tight junctions. Key mechanisms of tight junction damage from inside and outside cells are disruption of the actin cytoskeleton and matrix metalloproteinase activity, respectively. Viral proteins acting in BBB disruption are described for HIV-1, currently the most studied encephalitic virus; other viruses are also discussed.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 22564250      PMCID： PMC3367119          DOI： 10.1016/j.tim.2012.03.009

Source DB:  PubMed          Journal:  Trends Microbiol        ISSN： 0966-842X            Impact factor:   17.079


  94 in total

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Authors:  C J Cohen; J T Shieh; R J Pickles; T Okegawa; J T Hsieh; J M Bergelson
Journal:  Proc Natl Acad Sci U S A       Date:  2001-12-04       Impact factor: 11.205

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Authors:  Sara Salinas; Giampietro Schiavo; Eric J Kremer
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3.  Oxidative stress activates protein tyrosine kinase and matrix metalloproteinases leading to blood-brain barrier dysfunction.

Authors:  James Haorah; Servio H Ramirez; Kathy Schall; Daniel Smith; Rita Pandya; Yuri Persidsky
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4.  Junction adhesion molecule is a receptor for reovirus.

Authors:  E S Barton; J C Forrest; J L Connolly; J D Chappell; Y Liu; F J Schnell; A Nusrat; C A Parkos; T S Dermody
Journal:  Cell       Date:  2001-02-09       Impact factor: 41.582

5.  Human immunodeficiency virus infection of human astrocytes disrupts blood-brain barrier integrity by a gap junction-dependent mechanism.

Authors:  Eliseo A Eugenin; Janice E Clements; M Christine Zink; Joan W Berman
Journal:  J Neurosci       Date:  2011-06-29       Impact factor: 6.167

Review 6.  Subversion of the actin cytoskeleton during viral infection.

Authors:  Matthew P Taylor; Orkide O Koyuncu; Lynn W Enquist
Journal:  Nat Rev Microbiol       Date:  2011-04-27       Impact factor: 60.633

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8.  Human immunodeficiency virus type 1 gp120-mediated disruption of tight junction proteins by induction of proteasome-mediated degradation of zonula occludens-1 and -2 in human brain microvascular endothelial cells.

Authors:  Shinichi Nakamuta; Hiroshi Endo; Youichiro Higashi; Aoi Kousaka; Hiroshi Yamada; Mihiro Yano; Hiroshi Kido
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9.  Transcellular transport of West Nile virus-like particles across human endothelial cells depends on residues 156 and 159 of envelope protein.

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10.  Fluids and barriers of the CNS establish immune privilege by confining immune surveillance to a two-walled castle moat surrounding the CNS castle.

Authors:  Britta Engelhardt; Caroline Coisne
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  84 in total

Review 1.  Factors controlling permeability of the blood-brain barrier.

Authors:  Mohammed M A Almutairi; Chen Gong; Yuexian G Xu; Yanzhong Chang; Honglian Shi
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2.  MMPs/TIMPs imbalances in the peripheral blood and cerebrospinal fluid are associated with the pathogenesis of HIV-1-associated neurocognitive disorders.

Authors:  Yanyan Xing; Nicole Shepherd; Jie Lan; Wei Li; Sushmita Rane; Samir K Gupta; Shanxiang Zhang; Jun Dong; Qigui Yu
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3.  Profile of Cytokines and Chemokines Triggered by Wild-Type Strains of Rabies Virus in Mice.

Authors:  Camila Michele Appolinário; Susan Dora Allendorf; Marina Gea Peres; Bruna Devidé Ribeiro; Clóvis R Fonseca; Acácia Ferreira Vicente; João Marcelo A de Paula Antunes; Jane Megid
Journal:  Am J Trop Med Hyg       Date:  2015-12-28       Impact factor: 2.345

4.  A Protective Role for Interleukin-1 Signaling during Mouse Adenovirus Type 1-Induced Encephalitis.

Authors:  Luiza A Castro-Jorge; Carla D Pretto; Asa B Smith; Oded Foreman; Kelly E Carnahan; Katherine R Spindler
Journal:  J Virol       Date:  2017-01-31       Impact factor: 5.103

Review 5.  New insights into innate immune restriction of West Nile virus infection.

Authors:  Helen M Lazear; Michael S Diamond
Journal:  Curr Opin Virol       Date:  2014-12-31       Impact factor: 7.090

6.  The STING agonist 5,6-dimethylxanthenone-4-acetic acid (DMXAA) stimulates an antiviral state and protects mice against herpes simplex virus-induced neurological disease.

Authors:  Stacey Cerón; Brian J North; Sean A Taylor; David A Leib
Journal:  Virology       Date:  2019-01-06       Impact factor: 3.616

7.  Enhancement of blood-brain barrier permeability and reduction of tight junction protein expression are modulated by chemokines/cytokines induced by rabies virus infection.

Authors:  Qingqing Chai; Wen Q He; Ming Zhou; Huijun Lu; Zhen F Fu
Journal:  J Virol       Date:  2014-02-12       Impact factor: 5.103

8.  Viral Infection of the Central Nervous System and Neuroinflammation Precede Blood-Brain Barrier Disruption during Japanese Encephalitis Virus Infection.

Authors:  Fang Li; Yueyun Wang; Lan Yu; Shengbo Cao; Ke Wang; Jiaolong Yuan; Chong Wang; Kunlun Wang; Min Cui; Zhen F Fu
Journal:  J Virol       Date:  2015-03-11       Impact factor: 5.103

Review 9.  Mechanisms of Blood-Brain Barrier Disruption in Herpes Simplex Encephalitis.

Authors:  Hui Liu; Ke Qiu; Qiang He; Qiang Lei; Wei Lu
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Review 10.  Flaviviruses, an expanding threat in public health: focus on dengue, West Nile, and Japanese encephalitis virus.

Authors:  Carlo Amorin Daep; Jorge L Muñoz-Jordán; Eliseo Alberto Eugenin
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