BACKGROUND: Human granulocytic anaplasmosis (HGA) is a tick-borne rickettsial infectious disease. To date four cases of transfusion-transmitted anaplasmosis (TTA) have been described in the literature, and only one from leukoreduced red blood cells (RBCs). CASE REPORT: A 64-year-old patient with acute gastrointestinal blood loss was admitted to the hospital and received 5 units of prestorage leukoreduced RBCs. He was stabilized and discharged. He developed headache, fever, and chills 2 days after discharge and was readmitted. On Day 5 of his second admission polymorphonuclear leukocytes containing morulae consistent with HGA were reported in the peripheral smear. RESULTS: Samples from the recipient tested positive by polymerase chain reaction (PCR) for Anaplasma phagocytophilum, the causative agent of HGA and a segment from one of the five donors tested positive by both serology and PCR. CONCLUSION: Leukoreduction theoretically reduces the risk of TTA but does not interdict all infections. TTA requires consideration in recipients of RBC transfusion with unexplained fever.
BACKGROUND:Humangranulocytic anaplasmosis (HGA) is a tick-borne rickettsial infectious disease. To date four cases of transfusion-transmitted anaplasmosis (TTA) have been described in the literature, and only one from leukoreduced red blood cells (RBCs). CASE REPORT: A 64-year-old patient with acute gastrointestinal blood loss was admitted to the hospital and received 5 units of prestorage leukoreduced RBCs. He was stabilized and discharged. He developed headache, fever, and chills 2 days after discharge and was readmitted. On Day 5 of his second admission polymorphonuclear leukocytes containing morulae consistent with HGA were reported in the peripheral smear. RESULTS: Samples from the recipient tested positive by polymerase chain reaction (PCR) for Anaplasma phagocytophilum, the causative agent of HGA and a segment from one of the five donors tested positive by both serology and PCR. CONCLUSION: Leukoreduction theoretically reduces the risk of TTA but does not interdict all infections. TTA requires consideration in recipients of RBC transfusion with unexplained fever.
Authors: David Seidman; Nore Ojogun; Naomi J Walker; Juliana Mastronunzio; Amandeep Kahlon; Kathryn S Hebert; Sophia Karandashova; Daniel P Miller; Brittney K Tegels; Richard T Marconi; Erol Fikrig; Dori L Borjesson; Jason A Carlyon Journal: Cell Microbiol Date: 2014-04-03 Impact factor: 4.115
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Authors: David Seidman; Kathryn S Hebert; Hilary K Truchan; Daniel P Miller; Brittney K Tegels; Richard T Marconi; Jason A Carlyon Journal: PLoS Pathog Date: 2015-02-06 Impact factor: 7.464
Authors: Ruchika Goel; Lars F Westblade; Debra A Kessler; Maroun Sfeir; Sally Slavinski; Bryon Backenson; Linda Gebhardt; Kathleen Kane; Jeffrey Laurence; Douglas Scherr; James Bussel; J Stephen Dumler; Melissa M Cushing Journal: Emerg Infect Dis Date: 2018-08 Impact factor: 6.883