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Literature DB >> 22563100

Phenotypic discrepancies in acetyl-CoA carboxylase 2-deficient mice.

Kyle L Hoehn, Nigel Turner, George J Cooney, David E James.

Abstract

Entities: Gene Species

Mesh：

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Year: 2012 PMID： 22563100 PMCID： PMC3346128 DOI： 10.1074/jbc.O112.356915

Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157

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5 in total

1. Acetyl-CoA carboxylase 2-/- mutant mice are protected against fatty liver under high-fat, high-carbohydrate dietary and de novo lipogenic conditions.

Authors: Lutfi Abu-Elheiga; Hongmei Wu; Ziwei Gu; Rubin Bressler; Salih J Wakil
Journal: J Biol Chem Date: 2012-02-23 Impact factor: 5.157

2. Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2.

Authors: L Abu-Elheiga; M M Matzuk; K A Abo-Hashema; S J Wakil
Journal: Science Date: 2001-03-30 Impact factor: 47.728

3. Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity.

Authors: Cheol Soo Choi; David B Savage; Lutfi Abu-Elheiga; Zhen-Xiang Liu; Sheene Kim; Ameya Kulkarni; Alberto Distefano; Yu-Jin Hwang; Richard M Reznick; Roberto Codella; Dongyan Zhang; Gary W Cline; Salih J Wakil; Gerald I Shulman
Journal: Proc Natl Acad Sci U S A Date: 2007-10-08 Impact factor: 11.205

4. Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets.

Authors: Lutfi Abu-Elheiga; Wonkeun Oh; Parichher Kordari; Salih J Wakil
Journal: Proc Natl Acad Sci U S A Date: 2003-08-14 Impact factor: 11.205

5. Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity.

Authors: Kyle L Hoehn; Nigel Turner; Michael M Swarbrick; Donna Wilks; Elaine Preston; Yuwei Phua; Himani Joshi; Stuart M Furler; Mark Larance; Bronwyn D Hegarty; Simon J Leslie; Russell Pickford; Andrew J Hoy; Edward W Kraegen; David E James; Gregory J Cooney
Journal: Cell Metab Date: 2010-01 Impact factor: 27.287

5 in total

4 in total

Phenotypic discrepancies in acetyl-CoA carboxylase 2-deficient mice.

1. Acetyl-CoA carboxylase 2-/- mutant mice are protected against fatty liver under high-fat, high-carbohydrate dietary and de novo lipogenic conditions.

2. Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2.

3. Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity.

4. Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets.

5. Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity.

Review 1. Insulin signalling mechanisms for triacylglycerol storage.

2. Resveratrol compounds inhibit human holocarboxylase synthetase and cause a lean phenotype in Drosophila melanogaster.

Review 3. Structure and function of biotin-dependent carboxylases.

4. Minimal impact of age and housing temperature on the metabolic phenotype of Acc2-/- mice.