Literature DB >> 22562461

Genome-wide association studies: prospects and challenges for oral health.

J R Shaffer1, E Feingold, M L Marazita.   

Abstract

The genomic era of biomedical research has given rise to the genome-wide association study (GWAS) approach, which attempts to discover novel genes affecting an outcome by testing a large number (i.e., hundreds of thousands to millions) of genetic variants for association. This article discusses the issues surrounding the GWAS approach with emphasis on the prospects and challenges relevant to the oral health research community.

Mesh：

Year:  2012        PMID： 22562461      PMCID： PMC3383848          DOI： 10.1177/0022034512446968

Source DB:  PubMed          Journal:  J Dent Res        ISSN： 0022-0345            Impact factor:   6.116


  18 in total

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Authors:  J N MANSBRIDGE
Journal:  J Dent Res       Date:  1959 Mar-Apr       Impact factor: 6.116

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Journal:  J Periodontol       Date:  1991-05       Impact factor: 6.993

4.  A genome-wide association study identifies a locus for nonsyndromic cleft lip with or without cleft palate on 8q24.

Authors:  Struan F A Grant; Kai Wang; Haitao Zhang; Wendy Glaberson; Kiran Annaiah; Cecilia E Kim; Jonathan P Bradfield; Joseph T Glessner; Kelly A Thomas; Maria Garris; Edward C Frackelton; F George Otieno; Rosetta M Chiavacci; Hyun-Duck Nah; Richard E Kirschner; Hakon Hakonarson
Journal:  J Pediatr       Date:  2009-08-04       Impact factor: 4.406

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Journal:  Proc R Soc Med       Date:  1968-03

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Journal:  J Dent Res       Date:  2005-09       Impact factor: 6.116

7.  Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24.

Authors:  Stefanie Birnbaum; Kerstin U Ludwig; Heiko Reutter; Stefan Herms; Michael Steffens; Michele Rubini; Carlotta Baluardo; Melissa Ferrian; Nilma Almeida de Assis; Margrieta A Alblas; Sandra Barth; Jan Freudenberg; Carola Lauster; Gül Schmidt; Martin Scheer; Bert Braumann; Stefaan J Bergé; Rudolf H Reich; Franziska Schiefke; Alexander Hemprich; Simone Pötzsch; Regine P Steegers-Theunissen; Bernd Pötzsch; Susanne Moebus; Bernhard Horsthemke; Franz-Josef Kramer; Thomas F Wienker; Peter A Mossey; Peter Propping; Sven Cichon; Per Hoffmann; Michael Knapp; Markus M Nöthen; Elisabeth Mangold
Journal:  Nat Genet       Date:  2009-03-08       Impact factor: 38.330

Review 8.  Finding the missing heritability of complex diseases.

Authors:  Teri A Manolio; Francis S Collins; Nancy J Cox; David B Goldstein; Lucia A Hindorff; David J Hunter; Mark I McCarthy; Erin M Ramos; Lon R Cardon; Aravinda Chakravarti; Judy H Cho; Alan E Guttmacher; Augustine Kong; Leonid Kruglyak; Elaine Mardis; Charles N Rotimi; Montgomery Slatkin; David Valle; Alice S Whittemore; Michael Boehnke; Andrew G Clark; Evan E Eichler; Greg Gibson; Jonathan L Haines; Trudy F C Mackay; Steven A McCarroll; Peter M Visscher
Journal:  Nature       Date:  2009-10-08       Impact factor: 49.962

Review 9.  Subclinical features in non-syndromic cleft lip with or without cleft palate (CL/P): review of the evidence that subepithelial orbicularis oris muscle defects are part of an expanded phenotype for CL/P.

Authors:  Mary L Marazita
Journal:  Orthod Craniofac Res       Date:  2007-05       Impact factor: 1.826

10.  Heritable patterns of tooth decay in the permanent dentition: principal components and factor analyses.

Authors:  John R Shaffer; Eleanor Feingold; Xiaojing Wang; Karen T Tcuenco; Daniel E Weeks; Rebecca S DeSensi; Deborah E Polk; Steve Wendell; Robert J Weyant; Richard Crout; Daniel W McNeil; Mary L Marazita
Journal:  BMC Oral Health       Date:  2012-03-09       Impact factor: 2.757
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  2 in total

1.  Presentation of potential genes and deleterious variants associated with non-syndromic hearing loss: a computational approach.

Authors:  Manisha Ray; Surya Narayan Rath; Saurav Sarkar; Mukund Namdev Sable
Journal:  Genomics Inform       Date:  2022-03-31

2.  Polymorphisms of MFGE8 are associated with susceptibility and clinical manifestations through gene expression modulation in Koreans with systemic lupus erythematosus.

Authors:  Wook-Young Baek; Ji-Min Woo; Hyoun-Ah Kim; Ju-Yang Jung; Chang-Hee Suh
Journal:  Sci Rep       Date:  2019-12-06       Impact factor: 4.379
  2 in total

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