Literature DB >> 22562152

The updated biology of hypoxia-inducible factor.

Samantha N Greer1, Julie L Metcalf, Yi Wang, Michael Ohh.   

Abstract

Oxygen is essential for eukaryotic life and is inextricably linked to the evolution of multicellular organisms. Proper cellular response to changes in oxygen tension during normal development or pathological processes, such as cardiovascular disease and cancer, is ultimately regulated by the transcription factor, hypoxia-inducible factor (HIF). Over the past decade, unprecedented molecular insight has been gained into the mammalian oxygen-sensing pathway involving the canonical oxygen-dependent prolyl-hydroxylase domain-containing enzyme (PHD)-von Hippel-Lindau tumour suppressor protein (pVHL) axis and its connection to cellular metabolism. Here we review recent notable advances in the field of hypoxia that have shaped a more complex model of HIF regulation and revealed unique roles of HIF in a diverse range of biological processes, including immunity, development and stem cell biology.

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Year:  2012        PMID： 22562152      PMCID： PMC3365421          DOI： 10.1038/emboj.2012.125

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  131 in total

1.  Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity.

Authors:  Eoin P Cummins; Edurne Berra; Katrina M Comerford; Amandine Ginouves; Kathleen T Fitzgerald; Fergal Seeballuck; Catherine Godson; Jens E Nielsen; Paul Moynagh; Jacques Pouyssegur; Cormac T Taylor
Journal:  Proc Natl Acad Sci U S A       Date:  2006-11-17       Impact factor: 11.205

2.  Reduced oxygen concentration enhances conversion of embryonic stem cells to epiblast stem cells.

Authors:  Toshiyuki Takehara; Takeshi Teramura; Yuta Onodera; Chiaki Hamanishi; Kanji Fukuda
Journal:  Stem Cells Dev       Date:  2011-10-18       Impact factor: 3.272

3.  The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis.

Authors:  P H Maxwell; M S Wiesener; G W Chang; S C Clifford; E C Vaux; M E Cockman; C C Wykoff; C W Pugh; E R Maher; P J Ratcliffe
Journal:  Nature       Date:  1999-05-20       Impact factor: 49.962

4.  Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.

Authors:  P Jaakkola; D R Mole; Y M Tian; M I Wilson; J Gielbert; S J Gaskell; A von Kriegsheim; H F Hebestreit; M Mukherji; C J Schofield; P H Maxwell; C W Pugh; P J Ratcliffe
Journal:  Science       Date:  2001-04-05       Impact factor: 47.728

5.  Mitochondrial function controls proliferation and early differentiation potential of embryonic stem cells.

Authors:  Sudip Mandal; Anne G Lindgren; Anand S Srivastava; Amander T Clark; Utpal Banerjee
Journal:  Stem Cells       Date:  2011-03       Impact factor: 6.277

6.  An essential role for p300/CBP in the cellular response to hypoxia.

Authors:  Z Arany; L E Huang; R Eckner; S Bhattacharya; C Jiang; M A Goldberg; H F Bunn; D M Livingston
Journal:  Proc Natl Acad Sci U S A       Date:  1996-11-12       Impact factor: 11.205

7.  Cutting edge: An in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity.

Authors:  Timothy J Harris; Joseph F Grosso; Hung-Rong Yen; Hong Xin; Marcin Kortylewski; Emilia Albesiano; Edward L Hipkiss; Derese Getnet; Monica V Goldberg; Charles H Maris; Franck Housseau; Hua Yu; Drew M Pardoll; Charles G Drake
Journal:  J Immunol       Date:  2007-10-01       Impact factor: 5.422

Review 8.  Interdependence of hypoxic and innate immune responses.

Authors:  Victor Nizet; Randall S Johnson
Journal:  Nat Rev Immunol       Date:  2009-09       Impact factor: 53.106

9.  Regulation of endocytosis via the oxygen-sensing pathway.

Authors:  Yi Wang; Olga Roche; Mathew S Yan; Greg Finak; Andrew J Evans; Julie L Metcalf; Bridgid E Hast; Sara C Hanna; Bill Wondergem; Kyle A Furge; Meredith S Irwin; William Y Kim; Bin T Teh; Sergio Grinstein; Morag Park; Philip A Marsden; Michael Ohh
Journal:  Nat Med       Date:  2009-03-01       Impact factor: 53.440

10.  Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1.

Authors:  G L Semenza; B H Jiang; S W Leung; R Passantino; J P Concordet; P Maire; A Giallongo
Journal:  J Biol Chem       Date:  1996-12-20       Impact factor: 5.157
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  207 in total

Review 1.  Hypoxia, notch signalling, and prostate cancer.

Authors:  Laure Marignol; Karla Rivera-Figueroa; Thomas Lynch; Donal Hollywood
Journal:  Nat Rev Urol       Date:  2013-05-28       Impact factor: 14.432

2.  Hypoxia-inducible factors have distinct and stage-specific roles during reprogramming of human cells to pluripotency.

Authors:  Julie Mathieu; Wenyu Zhou; Yalan Xing; Henrik Sperber; Amy Ferreccio; Zsuzsa Agoston; Kavitha T Kuppusamy; Randall T Moon; Hannele Ruohola-Baker
Journal:  Cell Stem Cell       Date:  2014-03-20       Impact factor: 24.633

Review 3.  Metabolic remodeling in early development and cardiomyocyte maturation.

Authors:  Rebecca Ellen Kreipke; Yuliang Wang; Jason Wayne Miklas; Julie Mathieu; Hannele Ruohola-Baker
Journal:  Semin Cell Dev Biol       Date:  2016-02-18       Impact factor: 7.727

4.  Gerometabolites: the pseudohypoxic aging side of cancer oncometabolites.

Authors:  Javier A Menendez; Tomás Alarcón; Jorge Joven
Journal:  Cell Cycle       Date:  2014-02-03       Impact factor: 4.534

5.  Loss of hypoxia-inducible factor 2 alpha in the lung alveolar epithelium of mice leads to enhanced eosinophilic inflammation in cobalt-induced lung injury.

Authors:  Steven P Proper; Yogesh Saini; Krista K Greenwood; Lori A Bramble; Nathaniel J Downing; Jack R Harkema; John J Lapres
Journal:  Toxicol Sci       Date:  2013-11-11       Impact factor: 4.849

Review 6.  Carbon dioxide-sensing in organisms and its implications for human disease.

Authors:  Eoin P Cummins; Andrew C Selfridge; Peter H Sporn; Jacob I Sznajder; Cormac T Taylor
Journal:  Cell Mol Life Sci       Date:  2013-09-18       Impact factor: 9.261

7.  Variants in two adjacent genes, EGLN2 and CYP2A6, influence smoking behavior related to disease risk via different mechanisms.

Authors:  A Joseph Bloom; Timothy B Baker; Li-Shiun Chen; Naomi Breslau; Dorothy Hatsukami; Laura J Bierut; Alison Goate
Journal:  Hum Mol Genet       Date:  2013-09-17       Impact factor: 6.150

8.  Hypoxia potentiates allergen induction of HIF-1α, chemokines, airway inflammation, TGF-β1, and airway remodeling in a mouse model.

Authors:  Kwang Je Baek; Jae Youn Cho; Peter Rosenthal; Laura E Crotty Alexander; Victor Nizet; David H Broide
Journal:  Clin Immunol       Date:  2013-02-21       Impact factor: 3.969

9.  Hyperbaric oxygen preconditioning attenuates hyperglycemia-enhanced hemorrhagic transformation by inhibiting matrix metalloproteinases in focal cerebral ischemia in rats.

Authors:  Yoshiteru Soejima; Qin Hu; Paul R Krafft; Mutsumi Fujii; Jiping Tang; John H Zhang
Journal:  Exp Neurol       Date:  2013-03-26       Impact factor: 5.330

Review 10.  Emerging applications for zebrafish as a model organism to study oxidative mechanisms and their roles in inflammation and vascular accumulation of oxidized lipids.

Authors:  Longhou Fang; Yury I Miller
Journal:  Free Radic Biol Med       Date:  2012-08-11       Impact factor: 7.376
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