Literature DB >> 22561819

Protective inflammasome activation in AMD.

Jing Chen1, Lois E H Smith.   

Abstract

Age-related macular degeneration (AMD) is the most common cause of blindness in the elderly. AMD progression is associated with alterations in inflammatory pathways and the immune system. A new study identifies a protective role for inflammasomes in AMD, suggesting that inflammasome activation might be manipulated as a potential therapeutic strategy for this condition (pages 791-798).

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Year:  2012        PMID： 22561819      PMCID： PMC3687521          DOI： 10.1038/nm.2761

Source DB:  PubMed          Journal:  Nat Med        ISSN： 1078-8956            Impact factor:   53.440


  10 in total

1.  Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration.

Authors:  Wei Chen; Dwight Stambolian; Albert O Edwards; Kari E Branham; Mohammad Othman; Johanna Jakobsdottir; Nirubol Tosakulwong; Margaret A Pericak-Vance; Peter A Campochiaro; Michael L Klein; Perciliz L Tan; Yvette P Conley; Atsuhiro Kanda; Laura Kopplin; Yanming Li; Katherine J Augustaitis; Athanasios J Karoukis; William K Scott; Anita Agarwal; Jaclyn L Kovach; Stephen G Schwartz; Eric A Postel; Matthew Brooks; Keith H Baratz; William L Brown; Alexander J Brucker; Anton Orlin; Gary Brown; Allen Ho; Carl Regillo; Larry Donoso; Lifeng Tian; Brian Kaderli; Dexter Hadley; Stephanie A Hagstrom; Neal S Peachey; Ronald Klein; Barbara E K Klein; Norimoto Gotoh; Kenji Yamashiro; Frederick Ferris Iii; Jesen A Fagerness; Robyn Reynolds; Lindsay A Farrer; Ivana K Kim; Joan W Miller; Marta Cortón; Angel Carracedo; Manuel Sanchez-Salorio; Elizabeth W Pugh; Kimberly F Doheny; Maria Brion; Margaret M Deangelis; Daniel E Weeks; Donald J Zack; Emily Y Chew; John R Heckenlively; Nagahisa Yoshimura; Sudha K Iyengar; Peter J Francis; Nicholas Katsanis; Johanna M Seddon; Jonathan L Haines; Michael B Gorin; Gonçalo R Abecasis; Anand Swaroop
Journal:  Proc Natl Acad Sci U S A       Date:  2010-04-12       Impact factor: 11.205

2.  Complement factor H polymorphism in age-related macular degeneration.

Authors:  Robert J Klein; Caroline Zeiss; Emily Y Chew; Jen-Yue Tsai; Richard S Sackler; Chad Haynes; Alice K Henning; John Paul SanGiovanni; Shrikant M Mane; Susan T Mayne; Michael B Bracken; Frederick L Ferris; Jurg Ott; Colin Barnstable; Josephine Hoh
Journal:  Science       Date:  2005-03-10       Impact factor: 47.728

3.  MiR-33 contributes to the regulation of cholesterol homeostasis.

Authors:  Katey J Rayner; Yajaira Suárez; Alberto Dávalos; Saj Parathath; Michael L Fitzgerald; Norimasa Tamehiro; Edward A Fisher; Kathryn J Moore; Carlos Fernández-Hernando
Journal:  Science       Date:  2010-05-13       Impact factor: 47.728

4.  NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components.

Authors:  Sarah L Doyle; Matthew Campbell; Ema Ozaki; Robert G Salomon; Andres Mori; Paul F Kenna; Gwyneth Jane Farrar; Anna-Sophia Kiang; Marian M Humphries; Ed C Lavelle; Luke A J O'Neill; Joe G Hollyfield; Peter Humphries
Journal:  Nat Med       Date:  2012-05       Impact factor: 53.440

5.  CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration.

Authors:  Christophe Combadière; Charles Feumi; William Raoul; Nicole Keller; Mathieu Rodéro; Adeline Pézard; Sophie Lavalette; Marianne Houssier; Laurent Jonet; Emilie Picard; Patrice Debré; Mirna Sirinyan; Philippe Deterre; Tania Ferroukhi; Salomon-Yves Cohen; Dominique Chauvaud; Jean-Claude Jeanny; Sylvain Chemtob; Francine Behar-Cohen; Florian Sennlaub
Journal:  J Clin Invest       Date:  2007-10       Impact factor: 14.808

6.  Impaired cholesterol efflux in senescent macrophages promotes age-related macular degeneration.

Authors:  Abdoulaye Sene; Aslam A Khan; Douglas Cox; Rei E I Nakamura; Andrea Santeford; Bryan M Kim; Rohini Sidhu; Michael D Onken; J William Harbour; Shira Hagbi-Levi; Itay Chowers; Peter A Edwards; Angel Baldan; John S Parks; Daniel S Ory; Rajendra S Apte
Journal:  Cell Metab       Date:  2013-04-02       Impact factor: 27.287

Review 7.  Apolipoprotein B-containing lipoproteins in retinal aging and age-related macular degeneration.

Authors:  Christine A Curcio; Mark Johnson; Jiahn-Dar Huang; Martin Rudolf
Journal:  J Lipid Res       Date:  2009-09-29       Impact factor: 5.922

8.  DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88.

Authors:  Valeria Tarallo; Yoshio Hirano; Bradley D Gelfand; Sami Dridi; Nagaraj Kerur; Younghee Kim; Won Gil Cho; Hiroki Kaneko; Benjamin J Fowler; Sasha Bogdanovich; Romulo J C Albuquerque; William W Hauswirth; Vince A Chiodo; Jennifer F Kugel; James A Goodrich; Steven L Ponicsan; Gautam Chaudhuri; Michael P Murphy; Joshua L Dunaief; Balamurali K Ambati; Yuichiro Ogura; Jae Wook Yoo; Dong-ki Lee; Patrick Provost; David R Hinton; Gabriel Núñez; Judit Z Baffi; Mark E Kleinman; Jayakrishna Ambati
Journal:  Cell       Date:  2012-04-26       Impact factor: 41.582

9.  The controversy over the association between statins use and progression of age-related macular degeneration: a mini review.

Authors:  Vasileios Peponis; Spyridon E Chalkiadakis; Stefanos Bonovas; Nikolaos M Sitaras
Journal:  Clin Ophthalmol       Date:  2010-08-09

10.  Seven new loci associated with age-related macular degeneration.

Authors:  Lars G Fritsche; Wei Chen; Matthew Schu; Brian L Yaspan; Yi Yu; Gudmar Thorleifsson; Donald J Zack; Satoshi Arakawa; Valentina Cipriani; Stephan Ripke; Robert P Igo; Gabriëlle H S Buitendijk; Xueling Sim; Daniel E Weeks; Robyn H Guymer; Joanna E Merriam; Peter J Francis; Gregory Hannum; Anita Agarwal; Ana Maria Armbrecht; Isabelle Audo; Tin Aung; Gaetano R Barile; Mustapha Benchaboune; Alan C Bird; Paul N Bishop; Kari E Branham; Matthew Brooks; Alexander J Brucker; William H Cade; Melinda S Cain; Peter A Campochiaro; Chi-Chao Chan; Ching-Yu Cheng; Emily Y Chew; Kimberly A Chin; Itay Chowers; David G Clayton; Radu Cojocaru; Yvette P Conley; Belinda K Cornes; Mark J Daly; Baljean Dhillon; Albert O Edwards; Evangelos Evangelou; Jesen Fagerness; Henry A Ferreyra; James S Friedman; Asbjorg Geirsdottir; Ronnie J George; Christian Gieger; Neel Gupta; Stephanie A Hagstrom; Simon P Harding; Christos Haritoglou; John R Heckenlively; Frank G Holz; Guy Hughes; John P A Ioannidis; Tatsuro Ishibashi; Peronne Joseph; Gyungah Jun; Yoichiro Kamatani; Nicholas Katsanis; Claudia N Keilhauer; Jane C Khan; Ivana K Kim; Yutaka Kiyohara; Barbara E K Klein; Ronald Klein; Jaclyn L Kovach; Igor Kozak; Clara J Lee; Kristine E Lee; Peter Lichtner; Andrew J Lotery; Thomas Meitinger; Paul Mitchell; Saddek Mohand-Saïd; Anthony T Moore; Denise J Morgan; Margaux A Morrison; Chelsea E Myers; Adam C Naj; Yusuke Nakamura; Yukinori Okada; Anton Orlin; M Carolina Ortube; Mohammad I Othman; Chris Pappas; Kyu Hyung Park; Gayle J T Pauer; Neal S Peachey; Olivier Poch; Rinki Ratna Priya; Robyn Reynolds; Andrea J Richardson; Raymond Ripp; Guenther Rudolph; Euijung Ryu; José-Alain Sahel; Debra A Schaumberg; Hendrik P N Scholl; Stephen G Schwartz; William K Scott; Humma Shahid; Haraldur Sigurdsson; Giuliana Silvestri; Theru A Sivakumaran; R Theodore Smith; Lucia Sobrin; Eric H Souied; Dwight E Stambolian; Hreinn Stefansson; Gwen M Sturgill-Short; Atsushi Takahashi; Nirubol Tosakulwong; Barbara J Truitt; Evangelia E Tsironi; André G Uitterlinden; Cornelia M van Duijn; Lingam Vijaya; Johannes R Vingerling; Eranga N Vithana; Andrew R Webster; H-Erich Wichmann; Thomas W Winkler; Tien Y Wong; Alan F Wright; Diana Zelenika; Ming Zhang; Ling Zhao; Kang Zhang; Michael L Klein; Gregory S Hageman; G Mark Lathrop; Kari Stefansson; Rando Allikmets; Paul N Baird; Michael B Gorin; Jie Jin Wang; Caroline C W Klaver; Johanna M Seddon; Margaret A Pericak-Vance; Sudha K Iyengar; John R W Yates; Anand Swaroop; Bernhard H F Weber; Michiaki Kubo; Margaret M Deangelis; Thierry Léveillard; Unnur Thorsteinsdottir; Jonathan L Haines; Lindsay A Farrer; Iris M Heid; Gonçalo R Abecasis
Journal:  Nat Genet       Date:  2013-03-03       Impact factor: 38.330
  10 in total
  5 in total

Review 1.  Does Cataract Surgery Improve the Progression of Age-Related Macular Degeneration? A Meta-Analysis.

Authors:  Yuanyuan Liu; Qinhua Cai
Journal:  J Ophthalmol       Date:  2020-09-27       Impact factor: 1.909

Review 2.  Molecular Mechanisms Underlying the Therapeutic Role of Vitamin E in Age-Related Macular Degeneration.

Authors:  Genea Edwards; Caroline G Olson; Carlyn P Euritt; Peter Koulen
Journal:  Front Neurosci       Date:  2022-05-04       Impact factor: 5.152

Review 3.  New Highlights of Resveratrol: A Review of Properties against Ocular Diseases.

Authors:  Dominique Delmas; Clarisse Cornebise; Flavie Courtaut; Jianbo Xiao; Virginie Aires
Journal:  Int J Mol Sci       Date:  2021-01-28       Impact factor: 5.923

4.  The cell-matrix interface: a possible target for treating retinal vascular related pathologies.

Authors:  Gopalan Gnanaguru; William J Brunken
Journal:  J Ophthalmic Vis Res       Date:  2012-10

5.  Alterations of choroidal blood flow regulation in young healthy subjects with complement factor H polymorphism.

Authors:  Reinhard Told; Stefan Palkovits; Helmuth Haslacher; Sophie Frantal; Doreen Schmidl; Agnes Boltz; Michael Lasta; Semira Kaya; René M Werkmeister; Gerhard Garhöfer; Leopold Schmetterer
Journal:  PLoS One       Date:  2013-04-15       Impact factor: 3.240
  5 in total

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