Literature DB >> 22561182

Evaluation of carcinogenic hazard of diesel engine exhaust needs to consider revolutionary changes in diesel technology.

Roger O McClellan1, Thomas W Hesterberg, John C Wall.   

Abstract

Diesel engines, a special type of internal combustion engine, use heat of compression, rather than electric spark, to ignite hydrocarbon fuels injected into the combustion chamber. Diesel engines have high thermal efficiency and thus, high fuel efficiency. They are widely used in commerce prompting continuous improvement in diesel engines and fuels. Concern for health effects from exposure to diesel exhaust arose in the mid-1900s and stimulated development of emissions regulations and research to improve the technology and characterize potential health hazards. This included epidemiological, controlled human exposure, laboratory animal and mechanistic studies to evaluate potential hazards of whole diesel exhaust. The International Agency for Research on Cancer (1989) classified whole diesel exhaust as - "probably carcinogenic to humans". This classification stimulated even more stringent regulations for particulate matter that required further technological developments. These included improved engine control, improved fuel injection system, enhanced exhaust cooling, use of ultra low sulfur fuel, wall-flow high-efficiency exhaust particulate filters, exhaust catalysts, and crankcase ventilation filtration. The composition of New Technology Diesel Exhaust (NTDE) is qualitatively different and the concentrations of particulate constituents are more than 90% lower than for Traditional Diesel Exhaust (TDE). We recommend that future reviews of carcinogenic hazards of diesel exhaust evaluate NTDE separately from TDE.
Copyright © 2012 Elsevier Inc. All rights reserved.

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Year:  2012        PMID: 22561182     DOI: 10.1016/j.yrtph.2012.04.005

Source DB:  PubMed          Journal:  Regul Toxicol Pharmacol        ISSN: 0273-2300            Impact factor:   3.271


  16 in total

1.  Health effects research and regulation of diesel exhaust: an historical overview focused on lung cancer risk.

Authors:  Thomas W Hesterberg; Christopher M Long; William B Bunn; Charles A Lapin; Roger O McClellan; Peter A Valberg
Journal:  Inhal Toxicol       Date:  2012-06-04       Impact factor: 2.724

2.  A systematic review of the health effects associated with the inhalation of particle-filtered and whole diesel exhaust.

Authors:  Chelsea A Weitekamp; Lukas B Kerr; Laura Dishaw; Jennifer Nichols; McKayla Lein; Michael J Stewart
Journal:  Inhal Toxicol       Date:  2020-02-26       Impact factor: 2.724

3.  Combined Toxicity of Metal Nanoparticles: Comparison of Individual and Mixture Particles Effect.

Authors:  Ayse Basak Engin
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

4.  Factors and Trends Affecting the Identification of a Reliable Biomarker for Diesel Exhaust Exposure.

Authors:  David A Morgott
Journal:  Crit Rev Environ Sci Technol       Date:  2014-08       Impact factor: 12.561

Review 5.  Potential hazards associated with combustion of bio-derived versus petroleum-derived diesel fuel.

Authors:  Jürgen Bünger; Jürgen Krahl; Olaf Schröder; Lasse Schmidt; Götz A Westphal
Journal:  Crit Rev Toxicol       Date:  2012-08-08       Impact factor: 5.635

6.  Regulated and unregulated emissions from modern 2010 emissions-compliant heavy-duty on-highway diesel engines.

Authors:  Imad A Khalek; Matthew G Blanks; Patrick M Merritt; Barbara Zielinska
Journal:  J Air Waste Manag Assoc       Date:  2015-08       Impact factor: 2.235

7.  Reanalysis of the DEMS nested case-control study of lung cancer and diesel exhaust: suitability for quantitative risk assessment.

Authors:  Kenny S Crump; Cynthia Van Landingham; Suresh H Moolgavkar; Roger McClellan
Journal:  Risk Anal       Date:  2015-04-10       Impact factor: 4.000

8.  Mortality Benefits and Control Costs of Improving Air Quality in Mexico City: The Case of Heavy Duty Diesel Vehicles.

Authors:  John S Evans; Leonora Rojas-Bracho; James K Hammitt; Douglas W Dockery
Journal:  Risk Anal       Date:  2020-12-24       Impact factor: 4.000

9.  Mutagenicity of biodiesel or diesel exhaust particles and the effect of engine operating conditions.

Authors:  Elena R Kisin; X C Shi; Michael J Keane; Aleksandar B Bugarski; Anna A Shvedova
Journal:  J Environ Eng Ecol Sci       Date:  2013-03-09

10.  Diesel engine exhaust and lung cancer risks - evaluation of the meta-analysis by Vermeulen et al. 2014.

Authors:  Peter Morfeld; Michael Spallek
Journal:  J Occup Med Toxicol       Date:  2015-08-12       Impact factor: 2.646

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