Literature DB >> 22559986

Genetic regulation of thymocyte progenitor aging.

Beata Berent-Maoz1, Encarnacion Montecino-Rodriguez, Kenneth Dorshkind.   

Abstract

The number of T cell progenitors is significantly reduced in the involuted thymus, and the growth and developmental potential of the few cells that are present is severely attenuated. This review provides an overview of how aging affects T cell precursors before and following entry into the thymus and discusses the age-related genetic changes that may occur in them. Finally, interventions that rejuvenate thymopoiesis in the elderly by targeting T cell progenitors are discussed.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 22559986      PMCID： PMC3415574          DOI： 10.1016/j.smim.2012.04.006

Source DB:  PubMed          Journal:  Semin Immunol        ISSN： 1044-5323            Impact factor:   11.130


  88 in total

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Review 6.  Diminished immune responses with aging predispose older adults to common and uncommon influenza complications.

Authors:  Spencer R Keilich; Jenna M Bartley; Laura Haynes
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Review 7.  The Confluence of Sex Hormones and Aging on Immunity.

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9.  Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice.

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  9 in total

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