BACKGROUND: About 25% of schizophrenia patients with auditory hallucinations are refractory to pharmacotherapy and electroconvulsive therapy. We conducted a deep transcranial magnetic stimulation (TMS) pilot study in order to evaluate the potential clinical benefit of repeated left temporoparietal cortex stimulation in these patients. The results were encouraging, but a sham-controlled study was needed to rule out a placebo effect. METHODS: A total of 18 schizophrenic patients with refractory auditory hallucinations were recruited, from Beer Yaakov MHC and other hospitals outpatient populations. Patients received 10 daily treatment sessions with low-frequency (1 Hz for 10 min) deep TMS applied over the left temporoparietal cortex, using the H1 coil at the intensity of 110% of the motor threshold. Procedure was either real or sham according to patient randomization. Patients were evaluated via the Auditory Hallucinations Rating Scale, Scale for the Assessment of Positive Symptoms-Negative Symptoms, Clinical Global Impressions, and Quality of Life Questionnaire. RESULTS: In all, 10 patients completed the treatment (10 TMS sessions). Auditory hallucination scores of both groups improved; however, there was no statistical difference in any of the scales between the active and the sham treated groups. CONCLUSIONS: Low-frequency deep TMS to the left temporoparietal cortex using the protocol mentioned above has no statistically significant effect on auditory hallucinations or the other clinical scales measured in schizophrenic patients. TRIAL REGISTRATION: Clinicaltrials.gov identifier: NCT00564096.
RCT Entities:
BACKGROUND: About 25% of schizophreniapatients with auditory hallucinations are refractory to pharmacotherapy and electroconvulsive therapy. We conducted a deep transcranial magnetic stimulation (TMS) pilot study in order to evaluate the potential clinical benefit of repeated left temporoparietal cortex stimulation in these patients. The results were encouraging, but a sham-controlled study was needed to rule out a placebo effect. METHODS: A total of 18 schizophrenicpatients with refractory auditory hallucinations were recruited, from Beer Yaakov MHC and other hospitals outpatient populations. Patients received 10 daily treatment sessions with low-frequency (1 Hz for 10 min) deep TMS applied over the left temporoparietal cortex, using the H1 coil at the intensity of 110% of the motor threshold. Procedure was either real or sham according to patient randomization. Patients were evaluated via the Auditory Hallucinations Rating Scale, Scale for the Assessment of Positive Symptoms-Negative Symptoms, Clinical Global Impressions, and Quality of Life Questionnaire. RESULTS: In all, 10 patients completed the treatment (10 TMS sessions). Auditory hallucination scores of both groups improved; however, there was no statistical difference in any of the scales between the active and the sham treated groups. CONCLUSIONS: Low-frequency deep TMS to the left temporoparietal cortex using the protocol mentioned above has no statistically significant effect on auditory hallucinations or the other clinical scales measured in schizophrenicpatients. TRIAL REGISTRATION: Clinicaltrials.gov identifier: NCT00564096.
Authors: R E Hoffman; N N Boutros; R M Berman; E Roessler; A Belger; J H Krystal; D S Charney Journal: Biol Psychiatry Date: 1999-07-01 Impact factor: 13.382
Authors: Christina W Slotema; Jan Dirk Blom; Antoin D de Weijer; Kelly M Diederen; Rutger Goekoop; Jasper Looijestijn; Kirstin Daalman; Anne-Marije Rijkaart; René S Kahn; Hans W Hoek; Iris E C Sommer Journal: Biol Psychiatry Date: 2010-12-07 Impact factor: 13.382
Authors: Roman Gersner; Lindsay M Oberman; Maria J Sanchez; Nicolas Chiriboga; Harper L Kaye; Alvaro Pascual-Leone; Abraham Zangen; Alexander Rotenberg Journal: J Cent Nerv Syst Dis Date: 2022-05-09
Authors: Sanja Budisavljevic; Flavio Dell'Acqua; Frühling V Rijsdijk; Fergus Kane; Marco Picchioni; Philip McGuire; Timothea Toulopoulou; Anna Georgiades; Sridevi Kalidindi; Eugenia Kravariti; Robin M Murray; Declan G Murphy; Michael C Craig; Marco Catani Journal: J Neurosci Date: 2015-09-16 Impact factor: 6.167
Authors: R Gersner; L Oberman; M J Sanchez; N Chiriboga; H L Kaye; A Pascual-Leone; M Libenson; Y Roth; A Zangen; A Rotenberg Journal: Epilepsy Behav Case Rep Date: 2016-03-16
Authors: J S Gomes; A P Trevizol; D V Ducos; A Gadelha; B B Ortiz; A O Fonseca; H T Akiba; C C Azevedo; L S P Guimaraes; P Shiozawa; Q Cordeiro; A Lacerda; A M Dias Journal: Schizophr Res Cogn Date: 2018-02-20