| Literature DB >> 2255914 |
P D Aplan1, D P Lombardi, A M Ginsberg, J Cossman, V L Bertness, I R Kirsch.
Abstract
A fusion complementary DNA in the T cell line HSB-2 elucidates a provocative mechanism for the disruption of the putative hematopoietic transcription factor SCL. The fusion cDNA results from an interstitial deletion between a previously unknown locus, SIL (SCL interrupting locus), and the 5' untranslated region of SCL. Similar to 1;14 translocations, this deletion disrupts the SCL 5' regulatory region. This event is probably mediated by V-(D)-J recombinase activity, although neither locus is an immunoglobulin or a T cell receptor. Two other T cell lines, CEM and RPMI 8402, have essentially identical deletions. Thus, in lymphocytes, growth-affecting genes other than immune receptors risk rearrangements.Entities:
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Year: 1990 PMID： 2255914 DOI： 10.1126/science.2255914
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728