OBJECTIVE: To report on three patients with paraquat (PQ) intoxication surviving after combined therapy with hemoperfusion (HP), cyclophosphamide (CTX), and glucocorticoid. METHODS: Three patients suffered acute renal failure in a few days after ingesting a lethal amount of PQ. Chest computed tomography (CT) scans revealed obvious pulmonary inflammation, pleural effusion, and fibrous lesions several days after ingestion. HP was performed immediately, followed by large doses of glucocorticoid (methylprednisolone, 500 g/d) and CTX (approximately 4 g). RESULTS: After 50 d of treatments, all three patients were discharged in healthy condition, with chest CT showing small fibrous lesions, exudation, and both lungs clear of auscultation. CONCLUSIONS: The protective effect of the lungs may have been due to timely treatment at adequate doses.
OBJECTIVE: To report on three patients with paraquat (PQ) intoxication surviving after combined therapy with hemoperfusion (HP), cyclophosphamide (CTX), and glucocorticoid. METHODS: Three patients suffered acute renal failure in a few days after ingesting a lethal amount of PQ. Chest computed tomography (CT) scans revealed obvious pulmonary inflammation, pleural effusion, and fibrous lesions several days after ingestion. HP was performed immediately, followed by large doses of glucocorticoid (methylprednisolone, 500 g/d) and CTX (approximately 4 g). RESULTS: After 50 d of treatments, all three patients were discharged in healthy condition, with chest CT showing small fibrous lesions, exudation, and both lungs clear of auscultation. CONCLUSIONS: The protective effect of the lungs may have been due to timely treatment at adequate doses.
Authors: Ricardo Jorge Dinis-Oliveira; Paula Guedes de Pinho; Liliana Santos; Helena Teixeira; Teresa Magalhães; Agostinho Santos; Maria de Lourdes Bastos; Fernando Remião; José Alberto Duarte; Félix Carvalho Journal: PLoS One Date: 2009-09-25 Impact factor: 3.240
Authors: Klintean Wunnapuk; Fahim Mohammed; Indika Gawarammana; Xin Liu; Roger K Verbeeck; Nicholas A Buckley; Michael S Roberts; Flora T Musuamba Journal: Br J Clin Pharmacol Date: 2014-10 Impact factor: 4.335
Authors: Sheida Nasr Isfahani; Ziba Farajzadegan; Ali Mohammad Sabzghabaee; Alireza Rahimi; Shiva Samasamshariat; Nastaran Eizadi-Mood Journal: J Res Med Sci Date: 2019-01-31 Impact factor: 1.852