Literature DB >> 22555659

The power and pitfalls of IL-12.

Sid P Kerkar1, Nicholas P Restifo.   

Abstract

In this issue of Blood, Pegram and colleagues describe the ability to improve adoptive T-cell therapies by engineering T cells to secrete the potent proinflammatory cytokine IL-12.1 These exciting findings significantly extend previous observations made in a murine melanoma model targeting naturally occurring tumor antigens.2,3

Entities:  

Year:  2012        PMID： 22555659     DOI： 10.1182/blood-2012-03-415018

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


  10 in total

1.  Dendritic Cells in Irradiated Mice Trigger the Functional Plasticity and Antitumor Activity of Adoptively Transferred Tc17 Cells via IL12 Signaling.

Authors:  Jacob S Bowers; Michelle H Nelson; Sreenath Kundimi; Stefanie R Bailey; Logan W Huff; Kristina M Schwartz; David J Cole; Mark P Rubinstein; Chrystal M Paulos
Journal:  Clin Cancer Res       Date:  2015-04-22       Impact factor: 12.531

2.  Collapse of the tumor stroma is triggered by IL-12 induction of Fas.

Authors:  Sid P Kerkar; Anthony J Leonardi; Nicolas van Panhuys; Ling Zhang; Zhiya Yu; Joseph G Crompton; Jenny H Pan; Douglas C Palmer; Richard A Morgan; Steven A Rosenberg; Nicholas P Restifo
Journal:  Mol Ther       Date:  2013-04-09       Impact factor: 11.454

Review 3.  Targeting the tumor microenvironment to enhance antitumor immune responses.

Authors:  Kevin Van der Jeught; Lukasz Bialkowski; Lidia Daszkiewicz; Katrijn Broos; Cleo Goyvaerts; Dries Renmans; Sandra Van Lint; Carlo Heirman; Kris Thielemans; Karine Breckpot
Journal:  Oncotarget       Date:  2015-01-30

Review 4.  Turn Back the TIMe: Targeting Tumor Infiltrating Myeloid Cells to Revert Cancer Progression.

Authors:  Robin Maximilian Awad; Yannick De Vlaeminck; Johannes Maebe; Cleo Goyvaerts; Karine Breckpot
Journal:  Front Immunol       Date:  2018-08-31       Impact factor: 7.561

5.  Dynamic Changes of Urine Proteome in Rat Models Inoculated with Two Different Hepatoma Cell Lines.

Authors:  Yameng Zhang; Yufei Gao; Jing Wei; Youhe Gao
Journal:  J Oncol       Date:  2021-01-07       Impact factor: 4.375

6.  Irradiation Haematopoiesis Recovery Orchestrated by IL-12/IL-12Rβ1/TYK2/STAT3-Initiated Osteogenic Differentiation of Mouse Bone Marrow-Derived Mesenchymal Stem Cells.

Authors:  Fengjie Li; Rong Zhang; Changpeng Hu; Qian Ran; Yang Xiang; Lixin Xiang; Li Chen; Yang Yang; Shengwen Calvin Li; Gang Zhang; Zhongjun Li
Journal:  Front Cell Dev Biol       Date:  2021-09-03

7.  Assessing the Role of the Interleukin-12/STAT4 Axis in Breast Cancer by a Bioinformatics Approach.

Authors:  Angel Núñez-Marrero
Journal:  Int J Sci Basic Appl Res       Date:  2019-08-18

Review 8.  [Current Research of the Roles of IL-35 in Tumor Progression].

Authors:  Chongbiao Huang; Ye Tian; Yan Cui; Jie Xu; Liang Xin; Xueling Yang; Daliang Qi
Journal:  Zhongguo Fei Ai Za Zhi       Date:  2016-04-20

9.  Enhanced efficacy and limited systemic cytokine exposure with membrane-anchored interleukin-12 T-cell therapy in murine tumor models.

Authors:  Ling Zhang; John S Davies; Carylinda Serna; Zhiya Yu; Nicholas P Restifo; Steven A Rosenberg; Richard A Morgan; Christian S Hinrichs
Journal:  J Immunother Cancer       Date:  2020-01       Impact factor: 13.751

Review 10.  Tumor-Mediated Neutrophil Polarization and Therapeutic Implications.

Authors:  Sofia Raftopoulou; Paulina Valadez-Cosmes; Zala Nikita Mihalic; Rudolf Schicho; Julia Kargl
Journal:  Int J Mol Sci       Date:  2022-03-16       Impact factor: 5.923
  10 in total

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