| Literature DB >> 22555612 |
Hsia-Yuan Ying1, Shin-Tang Su, Pang-Hung Hsu, Che-Chang Chang, I-Ying Lin, Yu-Hsuan Tseng, Ming-Daw Tsai, Hsiu-Ming Shih, Kuo-I Lin.
Abstract
Transcriptional repressor B lymphocyte-induced maturation protein-1 (Blimp-1) is a master regulator of plasma cell differentiation. Here we show that Blimp-1 is covalently modified by SUMO1 at lysine 816, a modification mediated by SUMO E3 ligase PIAS1. Mutation of Blimp-1 lysine 816 reduces transcriptional repression--correlating with a reduced interaction with a histone deacetylase, HDAC2--and impairs differentiation of antibody-secreting cells. Thus, the SUMO pathway critically regulates Blimp-1 function during plasma cell differentiation.Entities:
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Year: 2012 PMID： 22555612 PMCID： PMC3388782 DOI： 10.1038/embor.2012.60
Source DB: PubMed Journal: EMBO Rep ISSN： 1469-221X Impact factor: 8.807