UNLABELLED: Encapsulated papillary carcinoma (EPC) of the breast is a distinct histological subtype characterised by malignant epithelial proliferation supported by fibrovascular stalks. Although EPC typically lacks myoepithelial cells, it shows indolent clinical course. The classification of EPC as an in situ, or invasive disease, remains a matter of debate. METHODS: In this study, the authors investigated a panel of invasion-associated markers in a series of EPC and compared their expression with control groups of non-papillary ductal carcinoma in situ (DCIS) and conventional invasive carcinomas. The expression pattern of four matrix metalloproteinases (MMP-1, MMP-2, MMP-7 and MMP-9), transforming growth factor receptor beta, vascular endothelial growth factor (VEGF) and E-cadherin were assessed in the tumour cell and/or stromal tissue, and the results were analysed. RESULTS: EPC showed higher expression levels of both MMP-1 and MMP-9 compared with DCIS, and no significant differences were observed between EPC and invasive carcinoma. Expression of MMP-2 and MMP-7 levels were similar in EPC and DCIS, but both showed lower levels compared with invasive tumours. EPC showed higher expression of E-cadherin and transforming growth factor receptor ß1 compared with both DCIS and invasive cancer. No difference in the stromal expression of MMPs or tumour expression of VEGF was detected. CONCLUSION: EPC exhibits an expression pattern of invasion-associated markers, which is intermediate in nature between DCIS and invasive cancer, providing further support of the unique biological features of EPC, and which may explain its clinically indolent behaviour.
UNLABELLED: Encapsulated papillary carcinoma (EPC) of the breast is a distinct histological subtype characterised by malignant epithelial proliferation supported by fibrovascular stalks. Although EPC typically lacks myoepithelial cells, it shows indolent clinical course. The classification of EPC as an in situ, or invasive disease, remains a matter of debate. METHODS: In this study, the authors investigated a panel of invasion-associated markers in a series of EPC and compared their expression with control groups of non-papillary ductal carcinoma in situ (DCIS) and conventional invasive carcinomas. The expression pattern of four matrix metalloproteinases (MMP-1, MMP-2, MMP-7 and MMP-9), transforming growth factor receptor beta, vascular endothelial growth factor (VEGF) and E-cadherin were assessed in the tumour cell and/or stromal tissue, and the results were analysed. RESULTS: EPC showed higher expression levels of both MMP-1 and MMP-9 compared with DCIS, and no significant differences were observed between EPC and invasive carcinoma. Expression of MMP-2 and MMP-7 levels were similar in EPC and DCIS, but both showed lower levels compared with invasive tumours. EPC showed higher expression of E-cadherin and transforming growth factor receptor ß1 compared with both DCIS and invasive cancer. No difference in the stromal expression of MMPs or tumour expression of VEGF was detected. CONCLUSION: EPC exhibits an expression pattern of invasion-associated markers, which is intermediate in nature between DCIS and invasive cancer, providing further support of the unique biological features of EPC, and which may explain its clinically indolent behaviour.
Authors: Emad A Rakha; Sunil Badve; Vincenzo Eusebi; Jorge S Reis-Filho; Stephen B Fox; David J Dabbs; Thomas Decker; Zsolt Hodi; Shu Ichihara; Andrew H S Lee; José Palacios; Andrea L Richardson; Anne Vincent-Salomon; Fernando C Schmitt; Puay-Hoon Tan; Gary M Tse; Ian O Ellis Journal: Histopathology Date: 2016-01 Impact factor: 5.087
Authors: Salvatore Piscuoglio; Charlotte K Y Ng; Luciano G Martelotto; Carey A Eberle; Catherine F Cowell; Rachael Natrajan; François-Clement Bidard; Leticia De Mattos-Arruda; Paul M Wilkerson; Odette Mariani; Anne Vincent-Salomon; Britta Weigelt; Jorge S Reis-Filho Journal: Mol Oncol Date: 2014-06-26 Impact factor: 6.603
Authors: Marjory Koller; Si-Qi Qiu; Matthijs D Linssen; Liesbeth Jansen; Wendy Kelder; Jakob de Vries; Inge Kruithof; Guo-Jun Zhang; Dominic J Robinson; Wouter B Nagengast; Annelies Jorritsma-Smit; Bert van der Vegt; Gooitzen M van Dam Journal: Nat Commun Date: 2018-09-18 Impact factor: 14.919