Literature DB >> 22554342

Dosimetric comparison between proton and photon beams in the moving gap region in cranio-spinal irradiation (CSI).

Chee-Wai Cheng1, Indra J Das, Shiv P Srivastava, Li Zhao, Mark Wolanski, Joseph Simmons, Peter A S Johnstone, Jeffrey C Buchsbaum.   

Abstract

PURPOSE: To investigate the moving gap region dosimetry in proton beam cranio-spinal irradiation (CSI) to provide optimal dose uniformity across the treatment volume.
MATERIAL AND METHODS: Proton beams of ranges 11.6 cm and 16 cm are used for the spine and the brain fields, respectively. Beam profiles for a 30 cm snout are first matched at the 50% level (hot match) on the computer. Feathering is simulated by shifting the dose profiles by a known distance two successive times to simulate a 2 × feathering scheme. The process is repeated for 2 mm and 4 mm gaps. Similar procedures are used to determine the dose profiles in the moving gap for a series of gap widths, 0-10 mm, and feathering step sizes, 4-10 mm, for a Varian iX 6MV beam. The proton and photon dose profiles in the moving gap region are compared.
RESULTS: The dose profiles in the moving gap exhibit valleys and peaks in both proton and photon beam CSI. The dose in the moving gap for protons is around 100% or higher for 0 mm gap, for both 5 and 10 mm feathering step sizes. When the field gap is comparable or larger than the penumbra, dose minima as low as 66% is obtained. The dosimetric characteristics for 6 MV photon beams can be made similar to those of the protons by appropriately combining gap width and feathering step size.
CONCLUSION: The dose in the moving gap region is determined by the lateral penumbras, the width of the gap and the feathering step size. The dose decreases with increasing gap width or decreasing feathering step size. The dosimetric characteristics are similar for photon and proton beams. However, proton CSI has virtually no exit dose and is beneficial for pediatric patients, whereas with photon beams the whole lung and abdomen receive non-negligible exit dose.

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Year:  2012        PMID: 22554342     DOI: 10.3109/0284186X.2012.681065

Source DB:  PubMed          Journal:  Acta Oncol        ISSN: 0284-186X            Impact factor:   4.089


  3 in total

Review 1.  Proton therapy for the treatment of children with CNS malignancies.

Authors:  Radhika Sreeraman; Daniel J Indelicato
Journal:  CNS Oncol       Date:  2014-03

2.  Simplified estimation method for dose distributions around field junctions in proton craniospinal irradiation.

Authors:  Haruo Yamashita; Yuki Kase; Shigeyuki Murayama
Journal:  Radiol Phys Technol       Date:  2016-09-01

3.  High LET-Like Radiation Tracks at the Distal Side of Accelerated Proton Bragg Peak.

Authors:  Dakota Horendeck; Kade D Walsh; Hirokazu Hirakawa; Akira Fujimori; Hisashi Kitamura; Takamitsu A Kato
Journal:  Front Oncol       Date:  2021-06-10       Impact factor: 6.244

  3 in total

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