Literature DB >> 2255387

Intranigral microinjection of neurotensin suppresses feeding in food deprived rats.

A W Vaughn1, A A Baumeister, M F Hawkins, T G Anticich.   

Abstract

This study was conducted to determine whether the substantia nigra is involved in the anorectic effect of centrally administered neurotensin. Microinjection of neurotensin (2.5 - 10.0 micrograms) into the substantia nigra produced a significant suppression of feeding in 18 hour food deprived rats. To determine if the anorectic effect resulted from a general impairment of sensory-motor functioning, eight behaviors were measured in a separate study. Significant effects were found in only two of the eight behavioral categories (sniffing and eating), and only at the highest neurotensin dose (10.0 micrograms). These results suggest that the substantia nigra may be involved in the anorectic effect of neurotensin.

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Year:  1990        PMID： 2255387     DOI： 10.1016/0028-3908(90)90147-j

Source DB:  PubMed          Journal:  Neuropharmacology        ISSN： 0028-3908            Impact factor:   5.250


  6 in total

1.  The effects of microinjection of neurotensin into the caudate nucleus of the rat brain on the performance and extinction of a conditioned motor reflex.

Authors:  N P Shugalev; A S Ol'shanskii; G Hartmann
Journal:  Neurosci Behav Physiol       Date:  2002 Jul-Aug

Review 2.  To ingest or rest? Specialized roles of lateral hypothalamic area neurons in coordinating energy balance.

Authors:  Juliette A Brown; Hillary L Woodworth; Gina M Leinninger
Journal:  Front Syst Neurosci       Date:  2015-02-18

3.  Distinct Types of Feeding Related Neurons in Mouse Hypothalamus.

Authors:  Yan Tang; Diego Benusiglio; Valery Grinevich; Longnian Lin
Journal:  Front Behav Neurosci       Date:  2016-05-18       Impact factor: 3.558

Review 4.  The Role of Central Neurotensin in Regulating Feeding and Body Weight.

Authors:  Jariel Ramirez-Virella; Gina M Leinninger
Journal:  Endocrinology       Date:  2021-05-01       Impact factor: 4.736

Review 5.  New Insights in the Control of Fat Homeostasis: The Role of Neurotensin.

Authors:  Ilaria Barchetta; Marco Giorgio Baroni; Olle Melander; Maria Gisella Cavallo
Journal:  Int J Mol Sci       Date:  2022-02-17       Impact factor: 6.208

6.  Genome-wide association study reveals genetic architecture of eating behavior in pigs and its implications for humans obesity by comparative mapping.

Authors:  Duy Ngoc Do; Anders Bjerring Strathe; Tage Ostersen; Just Jensen; Thomas Mark; Haja N Kadarmideen
Journal:  PLoS One       Date:  2013-08-19       Impact factor: 3.240
  6 in total

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