Ji-Wen Yang1, Yan-Chun Xu, Lin Sun, Xiao-Dan Tian. 1. Department of Ophthalmology, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.
Abstract
AIM: To investigate 5-hydroxytryptamine (5-HT) function and 5-HT receptor 2A (5-HT2A) mRNA expression in the formation of lens-induced myopia (LIM). METHODS: Lens-induced myopia construction method was applied to generate myopia on guinea pig right eye (LIM eye). RESULTS: LIM eyes formed significant myopia with longer axial length. 5-HT level in retina, choroids and sclera from LIM eyes was significantly higher than that in control group. 5-HT2A mRNA expression was also significantly up-regulated. CONCLUSION: Refraction lens could induce myopia in guinea pig and 5-HT may play an important role in the formation of myopia by binding with 5-HT2A receptor.
AIM: To investigate 5-hydroxytryptamine (5-HT) function and 5-HT receptor 2A (5-HT2A) mRNA expression in the formation of lens-induced myopia (LIM). METHODS: Lens-induced myopia construction method was applied to generate myopia on guinea pig right eye (LIM eye). RESULTS: LIM eyes formed significant myopia with longer axial length. 5-HT level in retina, choroids and sclera from LIM eyes was significantly higher than that in control group. 5-HT2A mRNA expression was also significantly up-regulated. CONCLUSION: Refraction lens could induce myopia in guinea pig and 5-HT may play an important role in the formation of myopia by binding with 5-HT2A receptor.
Authors: Arumugam R Muralidharan; Carla Lança; Sayantan Biswas; Veluchamy A Barathi; Low Wan Yu Shermaine; Saw Seang-Mei; Dan Milea; Raymond P Najjar Journal: Ther Adv Ophthalmol Date: 2021-12-19