Literature DB >> 225525

Neoplastic transformation of cultured Syrian hamster embryo cells by DNA of herpes simplex virus type 2.

R J Jariwalla, L Aurelian, P O Ts'o.   

Abstract

Syrian hamster embryo cells were transformed to a neoplastic phenotype after exposure to herpes simplex virus type 2 (S-1) DNA at concentrations (less than or equal to 0.01 microgram per 60-mm dish) at which infectivity was no longer demonstrable. Transformed cells manifested in vitro phenotypic properties characteristic of the neoplastic state, expressed herpes simplex virus-specific antigens, and induced invasive tumors in vivo. Transfection and transformation of Syrian hamster embryo cells with herpes simplex virus type 2 DNA or its fragments is a suitable system for investigating the structure and function of herpes simplex virus-transforming gene(s).

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Year:  1979        PMID： 225525      PMCID： PMC353337     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  25 in total

1.  AGAR SUSPENSION CULTURE FOR THE SELECTIVE ASSAY OF CELLS TRANSFORMED BY POLYOMA VIRUS.

Authors:  I MACPHERSON; L MONTAGNIER
Journal:  Virology       Date:  1964-06       Impact factor: 3.616

2.  SEDIMENTATION STUDIES OF THE SIZE AND SHAPE OF DNA.

Authors:  F W STUDIER
Journal:  J Mol Biol       Date:  1965-02       Impact factor: 5.469

3.  CLONAL GROWTH OF MAMMALIAN CELLS IN A CHEMICALLY DEFINED, SYNTHETIC MEDIUM.

Authors:  R G HAM
Journal:  Proc Natl Acad Sci U S A       Date:  1965-02       Impact factor: 11.205

4.  Oncogenic transformation of rat embryo fibroblasts with photoinactivated herpes simplex virus: rapid in vitro cloning of transformed cells.

Authors:  L S Kucera; J P Gusdon; I Edwards; G Herbst
Journal:  J Gen Virol       Date:  1977-06       Impact factor: 3.891

5.  Transfer of the gene for thymidine kinase to thymidine kinase-deficient human cells by purified herpes simplex viral DNA.

Authors:  S Bacchetti; F L Graham
Journal:  Proc Natl Acad Sci U S A       Date:  1977-04       Impact factor: 11.205

6.  Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells.

Authors:  M Wigler; S Silverstein; L S Lee; A Pellicer; Y c Cheng; R Axel
Journal:  Cell       Date:  1977-05       Impact factor: 41.582

7.  Comparison of DNA facilitators in the uptake and intracellular fate of infectious herpes simplex virus type 2 DNA.

Authors:  F E Farber
Journal:  Biochim Biophys Acta       Date:  1976-12-13

8.  Transformation of hamster embryo fibroblasts by a specific fragment of the herpes simplex virus genome.

Authors:  A Camacho; G Spear
Journal:  Cell       Date:  1978-11       Impact factor: 41.582

9.  Biochemical transformation of mouse cells by fragments of herpes simplex virus DNA.

Authors:  N J Maitland; J K McDougall
Journal:  Cell       Date:  1977-05       Impact factor: 41.582

10.  An improved technique for obtaining enhanced infectivity with herpes simplex virus type 1 DNA.

Authors:  N D Stow; N M Wilkie
Journal:  J Gen Virol       Date:  1976-12       Impact factor: 3.891
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  7 in total

1.  Tumorigenic transformation induced by a specific fragment of DNA from herpes simplex virus type 2.

Authors:  R J Jariwalla; L Aurelian; P O Ts'o
Journal:  Proc Natl Acad Sci U S A       Date:  1980-04       Impact factor: 11.205

2.  Focus formation and neoplastic transformation by herpes simplex virus type 2 inactivated intracellularly by 5-bromo-2'-deoxyuridine and near UV light.

Authors:  M M Manak; L Aurelian; P O Ts'o
Journal:  J Virol       Date:  1981-10       Impact factor: 5.103

3.  Immortalization and neoplastic transformation of normal diploid cells by defined cloned DNA fragments of herpes simplex virus type 2.

Authors:  R J Jariwalla; L Aurelian; P O Ts'o
Journal:  Proc Natl Acad Sci U S A       Date:  1983-10       Impact factor: 11.205

4.  DNA amplification and neoplastic transformation mediated by a herpes simplex DNA fragment containing cell-related sequences.

Authors:  R J Jariwalla; B Tanczos; C Jones; J Ortiz; S Salimi-Lopez
Journal:  Proc Natl Acad Sci U S A       Date:  1986-03       Impact factor: 11.205

5.  Induction of cervical neoplasia in the mouse by herpes simplex virus type 2 DNA.

Authors:  D D Anthony; W B Wentz; J W Reagan; A D Heggie
Journal:  Proc Natl Acad Sci U S A       Date:  1989-06       Impact factor: 11.205

6.  Identification of a virus-specific polypeptide associated with a transforming fragment (BglII-N) of herpes simplex virus type 2 DNA.

Authors:  J J Docherty; J H Subak-Sharpe; C M Preston
Journal:  J Virol       Date:  1981-10       Impact factor: 5.103

7.  Neoplastic transformation by a cloned human cytomegalovirus DNA fragment uniquely homologous to one of the transforming regions of herpes simplex virus type 2.

Authors:  D J Clanton; R J Jariwalla; C Kress; L J Rosenthal
Journal:  Proc Natl Acad Sci U S A       Date:  1983-06       Impact factor: 11.205
  7 in total

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