| Literature DB >> 22552144 |
Grzegorz Ira1, Philip J Hastings.
Abstract
The search for a homologous template is a fundamental, yet largely uncharacterized, reaction in DNA double-strand break repair. Two reports now demonstrate that broken chromosomes increase their movement and explore large volumes of nuclear space searching for a homologous template. Break mobility requires resection and recombination enzymes, as well as damage-checkpoint components.Entities:
Mesh：
Substances：
Year: 2012 PMID： 22552144 PMCID： PMC4495951 DOI： 10.1038/ncb2494
Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824