Literature DB >> 22552006

Proteasome inhibition leads to dephosphorylation and downregulation of protein expression of members of the Akt/mTOR pathway in MCL.

G Hutter, Y Zimmermann, M Rieken, E Hartmann, A Rosenwald, W Hiddemann, M Dreyling.   

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Year:  2012        PMID： 22552006     DOI： 10.1038/leu.2012.118

Source DB:  PubMed          Journal:  Leukemia        ISSN： 0887-6924            Impact factor:   11.528


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  5 in total

1.  MLN4924, an NAE inhibitor, suppresses AKT and mTOR signaling via upregulation of REDD1 in human myeloma cells.

Authors:  Yanyan Gu; Jonathan L Kaufman; Leon Bernal; Claire Torre; Shannon M Matulis; R Donald Harvey; Jing Chen; Shi-Yong Sun; Lawrence H Boise; Sagar Lonial
Journal:  Blood       Date:  2014-04-08       Impact factor: 22.113

2.  Discovery of PI-1840, a novel noncovalent and rapidly reversible proteasome inhibitor with anti-tumor activity.

Authors:  Aslamuzzaman Kazi; Sevil Ozcan; Awet Tecleab; Ying Sun; Harshani R Lawrence; Saïd M Sebti
Journal:  J Biol Chem       Date:  2014-02-25       Impact factor: 5.157

3.  Stabilization of DEPTOR sensitizes hypopharyngeal cancer to radiotherapy via targeting degradation.

Authors:  Xuecen Wang; Zhirui Cao; Xin Yue; Tingyu Liu; Gesi Wen; Dongmei Jiang; Weijian Wu; Liyuan Le; Yan Wang; Chengtao Wang; Ziyang Wang; Meng Jin; Meiyan Zhu; Shasha He; Xiaoyue Zhang; Xianzhang Bu; Ran-Yi Liu; Zhenwei Peng; Yong Chen
Journal:  Mol Ther Oncolytics       Date:  2022-08-05       Impact factor: 6.311

4.  Understanding the interplay between the proteasome pathway and autophagy in response to dual PI3K/mTOR inhibition in myeloma cells is essential for their effective clinical application.

Authors:  L I Aronson; E L Davenport; F Mirabella; G J Morgan; F E Davies
Journal:  Leukemia       Date:  2013-05-14       Impact factor: 11.528

5.  Protein targeting chimeric molecules specific for bromodomain and extra-terminal motif family proteins are active against pre-clinical models of multiple myeloma.

Authors:  Xiaohui Zhang; Hans C Lee; Fazal Shirazi; Veerabhadran Baladandayuthapani; Heather Lin; Isere Kuiatse; Hua Wang; Richard J Jones; Zuzana Berkova; Ram Kumar Singh; Jing Lu; Yimin Qian; Kanak Raina; Kevin G Coleman; Craig M Crews; Bingzong Li; Huihan Wang; Yared Hailemichael; Sheeba K Thomas; Zhiqiang Wang; R Eric Davis; Robert Z Orlowski
Journal:  Leukemia       Date:  2018-03-27       Impact factor: 11.528
  5 in total

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