Literature DB >> 22551813

CAPRISA 004 tenofovir microbicide trial: no impact of tenofovir gel on the HIV transmission bottleneck.

Ziyaad Valley-Omar1, Sengeziwe Sibeko, Jeffrey Anderson, Sarah Goodier, Lise Werner, Leslie Arney, Vivek Naranbhai, Florette Treurnicht, Melissa-Rose Abrahams, Gama Bandawe, Ronald Swanstrom, Quarraisha Abdool Karim, Salim S Abdool Karim, Carolyn Williamson.   

Abstract

Alterations of the genital mucosal barrier may influence the number of viruses transmitted from a human immunodeficiency virus-infected source host to the newly infected individual. We used heteroduplex tracking assay and single-genome sequencing to investigate the effect of a tenofovir-based microbicide gel on the transmission bottleneck in women who seroconverted during the CAPRISA 004 microbicide trial. Seventy-seven percent (17 of 22; 95% confidence interval [CI], 56%-90%) of women in the tenofovir gel arm were infected with a single virus compared with 92% (13 of 14; 95% CI, 67%->99%) in the placebo arm (P = .37). Tenofovir gel had no discernable impact on the transmission bottleneck.

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Year:  2012        PMID： 22551813      PMCID： PMC3415934          DOI： 10.1093/infdis/jis305

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  15 in total

1.  Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women.

Authors:  Quarraisha Abdool Karim; Salim S Abdool Karim; Janet A Frohlich; Anneke C Grobler; Cheryl Baxter; Leila E Mansoor; Ayesha B M Kharsany; Sengeziwe Sibeko; Koleka P Mlisana; Zaheen Omar; Tanuja N Gengiah; Silvia Maarschalk; Natasha Arulappan; Mukelisiwe Mlotshwa; Lynn Morris; Douglas Taylor
Journal:  Science       Date:  2010-07-19       Impact factor: 47.728

2.  MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0.

Authors:  Koichiro Tamura; Joel Dudley; Masatoshi Nei; Sudhir Kumar
Journal:  Mol Biol Evol       Date:  2007-05-07       Impact factor: 16.240

3.  Low-dose mucosal simian immunodeficiency virus infection restricts early replication kinetics and transmitted virus variants in rhesus monkeys.

Authors:  Jinyan Liu; Brandon F Keele; Hui Li; Sheila Keating; Philip J Norris; Angela Carville; Keith G Mansfield; Georgia D Tomaras; Barton F Haynes; Dror Kolodkin-Gal; Norman L Letvin; Beatrice H Hahn; George M Shaw; Dan H Barouch
Journal:  J Virol       Date:  2010-08-04       Impact factor: 5.103

4.  A substantial transmission bottleneck among newly and recently HIV-1-infected injection drug users in St Petersburg, Russia.

Authors:  Alexey E Masharsky; Elena N Dukhovlinova; Sergei V Verevochkin; Olga V Toussova; Roman V Skochilov; Jeffrey A Anderson; Irving Hoffman; Myron S Cohen; Ronald Swanstrom; Andrei P Kozlov
Journal:  J Infect Dis       Date:  2010-06-01       Impact factor: 5.226

5.  Effectiveness of COL-1492, a nonoxynol-9 vaginal gel, on HIV-1 transmission in female sex workers: a randomised controlled trial.

Authors:  Lut Van Damme; Gita Ramjee; Michel Alary; Bea Vuylsteke; Verapol Chandeying; Helen Rees; Pachara Sirivongrangson; Léonard Mukenge-Tshibaka; Virginie Ettiègne-Traoré; Charn Uaheowitchai; Salim S Abdool Karim; Benoît Mâsse; Jos Perriëns; Marie Laga
Journal:  Lancet       Date:  2002-09-28       Impact factor: 79.321

6.  Wide variation in the multiplicity of HIV-1 infection among injection drug users.

Authors:  Katharine J Bar; Hui Li; Annie Chamberland; Cecile Tremblay; Jean Pierre Routy; Truman Grayson; Chuanxi Sun; Shuyi Wang; Gerald H Learn; Charity J Morgan; Joseph E Schumacher; Barton F Haynes; Brandon F Keele; Beatrice H Hahn; George M Shaw
Journal:  J Virol       Date:  2010-04-07       Impact factor: 5.103

7.  Route of simian immunodeficiency virus inoculation determines the complexity but not the identity of viral variant populations that infect rhesus macaques.

Authors:  J L Greenier; C J Miller; D Lu; P J Dailey; F X Lü; K J Kunstman; S M Wolinsky; M L Marthas
Journal:  J Virol       Date:  2001-04       Impact factor: 5.103

8.  Sequential turnover of human immunodeficiency virus type 1 env throughout the course of infection.

Authors:  Tara M Riddle; Norah J Shire; Marc S Sherman; Kelly F Franco; Haynes W Sheppard; Julie A E Nelson
Journal:  J Virol       Date:  2006-09-06       Impact factor: 5.103

9.  A multiple-site-specific heteroduplex tracking assay as a tool for the study of viral population dynamics.

Authors:  W Resch; N Parkin; E L Stuelke; T Watkins; R Swanstrom
Journal:  Proc Natl Acad Sci U S A       Date:  2001-01-02       Impact factor: 11.205

10.  BEAST: Bayesian evolutionary analysis by sampling trees.

Authors:  Alexei J Drummond; Andrew Rambaut
Journal:  BMC Evol Biol       Date:  2007-11-08       Impact factor: 3.260
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  11 in total

1.  Replication Capacity of Viruses from Acute Infection Drives HIV-1 Disease Progression.

Authors:  Philippe Selhorst; Carina Combrinck; Nonkululeko Ndabambi; Sherazaan D Ismail; Melissa-Rose Abrahams; Miguel Lacerda; Natasha Samsunder; Nigel Garrett; Quarraisha Abdool Karim; Salim S Abdool Karim; Carolyn Williamson
Journal:  J Virol       Date:  2017-03-29       Impact factor: 5.103

2.  An Intravaginal Ring for the Simultaneous Delivery of an HIV-1 Maturation Inhibitor and Reverse-Transcriptase Inhibitor for Prophylaxis of HIV Transmission.

Authors:  Shweta R Ugaonkar; Justin T Clark; Lexie B English; Todd J Johnson; Karen W Buckheit; Robert J Bahde; Daniel H Appella; Robert W Buckheit; Patrick F Kiser
Journal:  J Pharm Sci       Date:  2015-07-06       Impact factor: 3.534

Review 3.  Microbicides: still a long road to success.

Authors:  Christophe Vanpouille; Anush Arakelyan; Leonid Margolis
Journal:  Trends Microbiol       Date:  2012-06-15       Impact factor: 17.079

4.  Antibody Maturation in Women Who Acquire HIV Infection While Using Antiretroviral Preexposure Prophylaxis.

Authors:  Oliver Laeyendecker; Andrew D Redd; Martha Nason; Andrew F Longosz; Quarraisha Abdool Karim; Vivek Naranbhai; Nigel Garrett; Susan H Eshleman; Salim S Abdool Karim; Thomas C Quinn
Journal:  J Infect Dis       Date:  2015-02-23       Impact factor: 5.226

5.  Intravaginal ring eluting tenofovir disoproxil fumarate completely protects macaques from multiple vaginal simian-HIV challenges.

Authors:  James M Smith; Rachna Rastogi; Ryan S Teller; Priya Srinivasan; Pedro M M Mesquita; Umadevi Nagaraja; Janet M McNicholl; R Michael Hendry; Chuong T Dinh; Amy Martin; Betsy C Herold; Patrick F Kiser
Journal:  Proc Natl Acad Sci U S A       Date:  2013-09-16       Impact factor: 11.205

6.  HIV disease progression in seroconvertors from the CAPRISA 004 tenofovir gel pre-exposure prophylaxis trial.

Authors:  Nigel J Garrett; Lise Werner; Nivashnee Naicker; Vivek Naranbhai; Sengeziwe Sibeko; Natasha Samsunder; Clive Gray; Carolyn Williamson; Lynn Morris; Quarraisha Abdool-Karim; Salim S Abdool-Karim
Journal:  J Acquir Immune Defic Syndr       Date:  2015-01-01       Impact factor: 3.731

Review 7.  Recommendations for the follow-up of study participants with breakthrough HIV infections during HIV/AIDS biomedical prevention studies.

Authors:  Paige Etter; Raphael Landovitz; Sengeziwe Sibeko; Magdalena E Sobieszczyk; Sharon A Riddler; Carissa Karg; Athe Tsibris; Jeffrey Schouten
Journal:  AIDS       Date:  2013-04-24       Impact factor: 4.177

8.  No evidence for selection of HIV-1 with enhanced gag-protease or Nef function among breakthrough infections in the CAPRISA 004 tenofovir microbicide trial.

Authors:  Denis R Chopera; Jaclyn K Mann; Philip Mwimanzi; Saleha Omarjee; Xiaomei T Kuang; Nonkululeko Ndabambi; Sarah Goodier; Eric Martin; Vivek Naranbhai; Salim Abdool Karim; Quarraisha Abdool Karim; Zabrina L Brumme; Thumbi Ndung'u; Carolyn Williamson; Mark A Brockman
Journal:  PLoS One       Date:  2013-08-28       Impact factor: 3.240

9.  Brief Report: Selection of HIV-1 Variants With Higher Transmission Potential by 1% Tenofovir Gel Microbicide.

Authors:  Nobubelo K Ngandu; Jonathan M Carlson; Denis R Chopera; Nonkululeko Ndabambi; Quarraisha Abdool Karim; Salim Abdool Karim; Carolyn Williamson
Journal:  J Acquir Immune Defic Syndr       Date:  2017-09-01       Impact factor: 3.731

10.  Development of methods for cross-sectional HIV incidence estimation in a large, community randomized trial.

Authors:  Oliver Laeyendecker; Michal Kulich; Deborah Donnell; Arnošt Komárek; Marek Omelka; Caroline E Mullis; Greg Szekeres; Estelle Piwowar-Manning; Agnes Fiamma; Ronald H Gray; Tom Lutalo; Charles S Morrison; Robert A Salata; Tsungai Chipato; Connie Celum; Erin M Kahle; Taha E Taha; Newton I Kumwenda; Quarraisha Abdool Karim; Vivek Naranbhai; Jairam R Lingappa; Michael D Sweat; Thomas Coates; Susan H Eshleman
Journal:  PLoS One       Date:  2013-11-13       Impact factor: 3.240
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