Literature DB >> 22551207

Oxidative damage of DNA, RNA and their metabolites in leukocytes, plasma and urine of Macaca mulatta: 8-oxoguanosine in urine is a useful marker for aging.

Fei Shi1, Ben Nie, Wei Gan, Xiao-Yang Zhou, Yasumitsu Takagi, Hiroshi Hayakawa, Mutsuo Sekiguchi, Jian-Ping Cai.   

Abstract

The levels of the oxidised forms of guanosine in leukocytes, plasma and urine of Macaca mulatta were determined using a sensitive method based on high-performance liquid chromatography-triple quadruple mass spectrometry (LC-MS/MS). The amounts of 8-oxo-7,8-dihydrodeoxyguanosine (8-oxo-dGsn) and 8-oxo-7,8-dihydroguanosin (8-oxoGsn), derived from DNA and RNA, respectively, increased with age in leukocytes. The measurement of the free forms of oxidised guanosine revealed similar age-dependent increases of 8-oxo-dGsn and 8-oxoGsn in both plasma and urine, which showed considerably larger amounts of 8-oxoGsn than 8-oxo-dGsn. The 8-oxoGsn content of urine could be a useful biomarker for evaluating aging, as age-dependent increases of 8-oxoGsn are more evident in urine compared to plasma and because urine samples are readily available.

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Year:  2012        PMID： 22551207     DOI： 10.3109/10715762.2012.689428

Source DB:  PubMed          Journal:  Free Radic Res        ISSN： 1029-2470


  8 in total

Review 1.  Metabolomics Signatures of Aging: Recent Advances.

Authors:  Sunil S Adav; Yulan Wang
Journal:  Aging Dis       Date:  2021-04-01       Impact factor: 6.745

2.  Transcriptional mutagenesis mediated by 8-oxoG induces translational errors in mammalian cells.

Authors:  Da-Peng Dai; Wei Gan; Hiroshi Hayakawa; Jia-Lou Zhu; Xiu-Qing Zhang; Guo-Xin Hu; Tao Xu; Zhe-Li Jiang; Li-Qun Zhang; Xue-Da Hu; Ben Nie; Yue Zhou; Jin Li; Xiao-Yang Zhou; Jian Li; Tie-Mei Zhang; Qing He; Dong-Ge Liu; Hai-Bo Chen; Nan Yang; Ping-Ping Zuo; Zhi-Xin Zhang; Huan-Ming Yang; Yao Wang; Samuel H Wilson; Yi-Xin Zeng; Jian-Ye Wang; Mutsuo Sekiguchi; Jian-Ping Cai
Journal:  Proc Natl Acad Sci U S A       Date:  2018-04-02       Impact factor: 11.205

3.  The Ratio of Plasma and Urinary 8-oxo-Gsn Could Be a Novel Evaluation Index for Patients with Chronic Kidney Disease.

Authors:  Yong-Hui Mao; Leng-Nan Xu; Qing-Hua Weng; Xiang-Yu Li; Ban Zhao; Jing-Jing Nie; Ji-Hong Hu; Li-Qun Zhang; Zhe Chen; Ming-Zhang Zuo; Sadayoshi Ito; Jian-Ping Cai
Journal:  Oxid Med Cell Longev       Date:  2018-01-17       Impact factor: 6.543

4.  Urinary 8-oxo-7,8-dihydroguanosine as a Potential Biomarker of Aging.

Authors:  Wei Gan; Xin-Le Liu; Ting Yu; Yuan-Gao Zou; Ting-Ting Li; Shuang Wang; Jin Deng; Lan-Lan Wang; Jian-Ping Cai
Journal:  Front Aging Neurosci       Date:  2018-02-27       Impact factor: 5.750

Review 5.  Role of RNA Oxidation in Neurodegenerative Diseases.

Authors:  Ziqian Liu; Xiatian Chen; Zhe Li; Wei Ye; Hongyan Ding; Peifeng Li; Lynn Htet Htet Aung
Journal:  Int J Mol Sci       Date:  2020-07-16       Impact factor: 5.923

6.  Is pre-heat necessary for the measurement of 8-oxo-7,8-dihydroguanosine and 8-oxo-7,8-dihydro-2'-deoxyguanosine in urine samples.

Authors:  Yutong Zou; Xiaoli Ma; Songlin Yu; Ling Qiu
Journal:  J Clin Lab Anal       Date:  2022-08-29       Impact factor: 3.124

7.  Age-dependent accumulation of 8-oxoguanine in the DNA and RNA in various rat tissues.

Authors:  Ben Nie; Wei Gan; Fei Shi; Guo-Xin Hu; Lian-Guo Chen; Hiroshi Hayakawa; Mutsuo Sekiguchi; Jian-Ping Cai
Journal:  Oxid Med Cell Longev       Date:  2013-04-29       Impact factor: 6.543

8.  Oxidative damage to nucleic acids and benzo(a)pyrene-7,8-diol-9,10-epoxide-DNA adducts and chromosomal aberration in children with psoriasis repeatedly exposed to crude coal tar ointment and UV radiation.

Authors:  Lenka Borska; Ctirad Andrys; Jan Krejsek; Vladimir Palicka; Marcela Chmelarova; Kvetoslava Hamakova; Jan Kremlacek; Zdenek Fiala
Journal:  Oxid Med Cell Longev       Date:  2014-08-12       Impact factor: 6.543
  8 in total

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