Literature DB >> 22549774

Uncovering of a short internal peptide activates a tRNA synthetase procytokine.

Peter S Lee1, Hui-Min Zhang, Alan G Marshall, Xiang-Lei Yang, Paul Schimmel.   

Abstract

In higher organisms, aminoacyl-tRNA synthetases developed receptor-mediated ex-translational functions that are activated by various natural mechanisms. Hydrogen-deuterium exchange combined with mass spectrometry and small-angle x-ray scattering showed that activation of the cytokine function of the 528-amino acid human tyrosyl-tRNA synthetase was associated with pinpointed uncovering of a miniature internal ELR tripeptide that triggers receptor signaling. The results reveal the structural simplicity of how the ex-translational function is implemented.

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Year:  2012        PMID： 22549774      PMCID： PMC3370235          DOI： 10.1074/jbc.C112.369439

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  30 in total

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Journal:  Science       Date:  1999-04-02       Impact factor: 47.728

2.  Genetic code in evolution: switching species-specific aminoacylation with a peptide transplant.

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Journal:  Adv Immunol       Date:  1994       Impact factor: 3.543

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Authors:  My-Nuong Vo; Xiang-Lei Yang; Paul Schimmel
Journal:  J Biol Chem       Date:  2011-02-10       Impact factor: 5.157

5.  Crystal structure of a human aminoacyl-tRNA synthetase cytokine.

Authors:  Xiang-Lei Yang; Robert J Skene; Duncan E McRee; Paul Schimmel
Journal:  Proc Natl Acad Sci U S A       Date:  2002-11-11       Impact factor: 11.205

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Authors:  Hui-Min Zhang; George M Bou-Assaf; Mark R Emmett; Alan G Marshall
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8.  Gain-of-function mutational activation of human tRNA synthetase procytokine.

Authors:  Xiang-Lei Yang; Mili Kapoor; Francella J Otero; Bonnie M Slike; Hiro Tsuruta; Ricardo Frausto; Alison Bates; Karla L Ewalt; David A Cheresh; Paul Schimmel
Journal:  Chem Biol       Date:  2007-12

9.  Enhanced digestion efficiency, peptide ionization efficiency, and sequence resolution for protein hydrogen/deuterium exchange monitored by Fourier transform ion cyclotron resonance mass spectrometry.

Authors:  Hui-Min Zhang; Sasa Kazazic; Tanner M Schaub; Jeremiah D Tipton; Mark R Emmett; Alan G Marshall
Journal:  Anal Chem       Date:  2008-12-01       Impact factor: 6.986

10.  Simultaneous reduction and digestion of proteins with disulfide bonds for hydrogen/deuterium exchange monitored by mass spectrometry.

Authors:  Hui-Min Zhang; Shaun M McLoughlin; Stephen D Frausto; Hengli Tang; Mark R Emmett; Alan G Marshall
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2.  Alternative stable conformation capable of protein misinteraction links tRNA synthetase to peripheral neuropathy.

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Review 3.  Architecture and metamorphosis.

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Journal:  Structure       Date:  2012-09-05       Impact factor: 5.006

Review 5.  Applications of hydrogen/deuterium exchange MS from 2012 to 2014.

Authors:  Gregory F Pirrone; Roxana E Iacob; John R Engen
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6.  A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol.

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7.  Alternative splicing creates two new architectures for human tyrosyl-tRNA synthetase.

Authors:  Zhiyi Wei; Zhiwen Xu; Xiaotian Liu; Wing-Sze Lo; Fei Ye; Ching-Fun Lau; Feng Wang; Jie J Zhou; Leslie A Nangle; Xiang-Lei Yang; Mingjie Zhang; Paul Schimmel
Journal:  Nucleic Acids Res       Date:  2016-01-14       Impact factor: 16.971
  7 in total

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