Literature DB >> 22549385

Synthesis and X-ray structure analysis of a heptacoordinate titanium(IV)-bis-chelate with enhanced in vivo antitumor efficacy.

Timo A Immel1, Martin Grützke, Anne-Katrin Späte, Ulrich Groth, Peter Öhlschläger, Thomas Huhn.   

Abstract

Chelate stabilization of a titanium(IV)-salan alkoxide by ligand exchange with 2,6-pyridinedicarboxylic acid (dipic) resulted in heptacoordinate complex 3 which is not redox-active, stable on silica gel and has increased aqueous stability. 3 is highly toxic in HeLa S3 and Hep G2 and has enhanced antitumor efficacy in a mouse cervical-cancer model.

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Year:  2012        PMID： 22549385     DOI： 10.1039/c2cc31624b

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  8 in total

Review 1.  A ubiquitous metal, difficult to track: towards an understanding of the regulation of titanium(iv) in humans.

Authors:  Sergio A Loza-Rosas; Manoj Saxena; Yamixa Delgado; Kavita Gaur; Mallesh Pandrala; Arthur D Tinoco
Journal:  Metallomics       Date:  2017-04-19       Impact factor: 4.526

2.  Expanding the Therapeutic Potential of the Iron Chelator Deferasirox in the Development of Aqueous Stable Ti(IV) Anticancer Complexes.

Authors:  Sergio A Loza-Rosas; Alexandra M Vázquez-Salgado; Kennett I Rivero; Lenny J Negrón; Yamixa Delgado; Josué A Benjamín-Rivera; Angel L Vázquez-Maldonado; Timothy B Parks; Charlene Munet-Colón; Arthur D Tinoco
Journal:  Inorg Chem       Date:  2017-06-23       Impact factor: 5.165

3.  Unusual Synergism of Transferrin and Citrate in the Regulation of Ti(IV) Speciation, Transport, and Toxicity.

Authors:  Arthur D Tinoco; Manoj Saxena; Shweta Sharma; Nicholas Noinaj; Yamixa Delgado; Ernesto P Quiñones González; Steven E Conklin; Nicole Zambrana; Sergio A Loza-Rosas; Timothy B Parks
Journal:  J Am Chem Soc       Date:  2016-04-26       Impact factor: 15.419

4.  Titanium Tackles the Endoplasmic Reticulum: A First Genomic Study on a Titanium Anticancer Metallodrug.

Authors:  Maya Miller; Anna Mellul; Maya Braun; Dana Sherill-Rofe; Emiliano Cohen; Zohar Shpilt; Irene Unterman; Ori Braitbard; Jacob Hochman; Edit Y Tshuva; Yuval Tabach
Journal:  iScience       Date:  2020-06-12

5.  Racemic vs. enantiopure inert Ti(iv) complex of a single diaminotetrakis(phenolato) ligand in anticancer activity toward human drug-sensitive and -resistant cancer cell lines.

Authors:  Maya Miller; Edit Y Tshuva
Journal:  RSC Adv       Date:  2018-11-27       Impact factor: 4.036

6.  Design, Synthesis, Computational, and Preclinical Evaluation of natTi/45Ti-Labeled Urea-Based Glutamate PSMA Ligand.

Authors:  Kristina Søborg Pedersen; Christina Baun; Karin Michaelsen Nielsen; Helge Thisgaard; Andreas Ingemann Jensen; Fedor Zhuravlev
Journal:  Molecules       Date:  2020-03-02       Impact factor: 4.411

Review 7.  Untold story of human cervical cancers: HPV-negative cervical cancer.

Authors:  Jae-Eun Lee; Yein Chung; Siyeon Rhee; Tae-Hyung Kim
Journal:  BMB Rep       Date:  2022-09       Impact factor: 5.041

8.  In Vivo Anticancer Activity of a Nontoxic Inert Phenolato Titanium Complex: High Efficacy on Solid Tumors Alone and Combined with Platinum Drugs.

Authors:  Nitzan Ganot; Ori Briaitbard; Asaad Gammal; Joseph Tam; Jacob Hochman; Edit Y Tshuva
Journal:  ChemMedChem       Date:  2018-10-19       Impact factor: 3.466
  8 in total

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