| Literature DB >> 2254926 |
W N Hunter1, K Smith, Z Derewenda, S J Harrop, J Habash, M S Islam, J R Helliwell, A H Fairlamb.
Abstract
We have obtained well-ordered single crystals of the flavoenzyme trypanothione reductase from Crithidia fasciculata. The crystals are tetragonal rods with unit cell dimensions a = 128.6 A, c = 92.5 A. The diffraction pattern corresponds to a primitive lattice. Laue class 4/m. Diffraction to better than 2.4 A has been recorded at the Daresbury Synchrotron. The accurate elucidation of the three-dimensional structure of this enzyme is required to support the rational design of compounds active against a variety of tropical diseases caused by trypanosomal parasites.Entities:
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Year: 1990 PMID： 2254926 DOI： 10.1016/S0022-2836(05)80314-6
Source DB: PubMed Journal: J Mol Biol ISSN： 0022-2836 Impact factor: 5.469