| Literature DB >> 22549138 |
Roberto Romeo1, Caterina Carnovale, Salvatore V Giofrè, Giovanni Romeo, Beatrice Macchi, Caterina Frezza, Francesca Marino-Merlo, Venerando Pistarà, Ugo Chiacchio.
Abstract
Truncated phosphonated C-1'-branched N,O-nucleosides have been synthesized in good yields by 1,3-dipolar cycloaddition methodology, starting from N-methyl-C-(diethoxyphosphoryl)nitrone 7. Preliminary biological assays show that β-anomers are able to inhibit HIV in vitro infection at concentrations in the micromolar range. Higher SI values with respect to AZT indicated that the compounds were endowed with low cytotoxicity.Entities:
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Year: 2012 PMID： 22549138 DOI： 10.1016/j.bmc.2012.03.047
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641