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Literature DB >> 22547071

Rab5 proteins regulate activation and localization of target of rapamycin complex 1.

Dave Bridges¹, Kaleigh Fisher, Sergey N Zolov, Tingting Xiong, Ken Inoki, Lois S Weisman, Alan R Saltiel.

Abstract

The mechanistic target of rapamycin (mTOR) complex 1 is regulated by small GTPase activators and localization signals. We examine here the role of the small GTPase Rab5 in the localization and activation of TORC1 in yeast and mammalian cells. Rab5 mutants disrupt mTORC1 activation and localization in mammalian cells, whereas disruption of the Rab5 homolog in yeast, Vps21, leads to decreased TORC1 function. Additionally, regulation of PI(3)P synthesis by Rab5 and Vps21 is essential for TORC1 function in both contexts.

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Year: 2012 PMID： 22547071 PMCID： PMC3375515 DOI： 10.1074/jbc.M111.334060

Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157

46 in total

1. Phosphatidylinositol-3-OH kinases are Rab5 effectors.

Authors: S Christoforidis; M Miaczynska; K Ashman; M Wilm; L Zhao; S C Yip; M D Waterfield; J M Backer; M Zerial
Journal: Nat Cell Biol Date: 1999-08 Impact factor: 28.824

2. A ubiquitin-binding motif required for intramolecular monoubiquitylation, the CUE domain.

Authors: Susan C Shih; Gali Prag; Smitha A Francis; Myra A Sutanto; James H Hurley; Linda Hicke
Journal: EMBO J Date: 2003-03-17 Impact factor: 11.598

3. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.

Authors: Ken Inoki; Yong Li; Tian Xu; Kun-Liang Guan
Journal: Genes Dev Date: 2003-07-17 Impact factor: 11.361

4. Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control.

Authors: Robbie Loewith; Estela Jacinto; Stephan Wullschleger; Anja Lorberg; José L Crespo; Débora Bonenfant; Wolfgang Oppliger; Paul Jenoe; Michael N Hall
Journal: Mol Cell Date: 2002-09 Impact factor: 17.970

5. SAC1 encodes a regulated lipid phosphoinositide phosphatase, defects in which can be suppressed by the homologous Inp52p and Inp53p phosphatases.

Authors: W E Hughes; R Woscholski; F T Cooke; R S Patrick; S K Dove; N Q McDonald; P J Parker
Journal: J Biol Chem Date: 2000-01-14 Impact factor: 5.157

6. Insulin can regulate GLUT4 internalization by signaling to Rab5 and the motor protein dynein.

Authors: J Huang; T Imamura; J M Olefsky
Journal: Proc Natl Acad Sci U S A Date: 2001-10-30 Impact factor: 11.205

7. Sac1 lipid phosphatase and Stt4 phosphatidylinositol 4-kinase regulate a pool of phosphatidylinositol 4-phosphate that functions in the control of the actin cytoskeleton and vacuole morphology.

Authors: M Foti; A Audhya; S D Emr
Journal: Mol Biol Cell Date: 2001-08 Impact factor: 4.138

8. Osmotic stress-induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p.

Authors: Cecilia J Bonangelino; Johnathan J Nau; Jason E Duex; Mikala Brinkman; Andrew E Wurmser; Jonathan D Gary; Scott D Emr; Lois S Weisman
Journal: J Cell Biol Date: 2002-03-11 Impact factor: 10.539

9. Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae.

Authors: A Kihara; T Noda; N Ishihara; Y Ohsumi
Journal: J Cell Biol Date: 2001-02-05 Impact factor: 10.539

10. Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb.

Authors: Andrew R Tee; Brendan D Manning; Philippe P Roux; Lewis C Cantley; John Blenis
Journal: Curr Biol Date: 2003-08-05 Impact factor: 10.834

40 in total

1. Rab5a suppresses autophagy to promote drug resistance in cancer cells.

Authors: Wenxia Xu; Qiqi Shi; Xiaoling Qian; Bingluo Zhou; Jinye Xu; Liyuan Zhu; Lifeng Feng; Hongchuan Jin; Xian Wang
Journal: Am J Transl Res Date: 2018-04-15 Impact factor: 4.060

Review 2. Role of the mammalian target of rapamycin pathway in lentiviral vector transduction of hematopoietic stem cells.

Authors: Cathy X Wang; Bruce E Torbett
Journal: Curr Opin Hematol Date: 2015-07 Impact factor: 3.284

3. Dynamin-dependent amino acid endocytosis activates mechanistic target of rapamycin complex 1 (mTORC1).

Authors: Shusaku Shibutani; Hana Okazaki; Hiroyuki Iwata
Journal: J Biol Chem Date: 2017-08-14 Impact factor: 5.157

Review 4. The autophagic roles of Rab small GTPases and their upstream regulators: a review.

Authors: Zsuzsanna Szatmári; Miklós Sass
Journal: Autophagy Date: 2014-06-04 Impact factor: 16.016

5. The nutrient stress-induced small GTPase Rab5 contributes to the activation of vesicle trafficking and vacuolar activity.

Authors: Kunio Nakatsukasa; Akira Kanada; Mariko Matsuzaki; Stuart D Byrne; Fumihiko Okumura; Takumi Kamura
Journal: J Biol Chem Date: 2014-07-25 Impact factor: 5.157