OBJECTIVE: To evaluate the effects of the standardized extract of fenugreek (Trigonella foenum-graecum L. Family: Leguminasae) seed (IND01) in animal models of peripheral neuropathy. METHODS: IND01 was prepared from fenugreek seeds and standardized by high performance liquid chromatography to a marker compound, trigonelline. The effects of daily oral administration of IND01 (50, 100 and 200 mg/kg) were studied in rats after partial sciatic nerve ligation (PSNL) and sciatic nerve crush injury (SNCI) during 30-days period. The measurements on thermal hyperalgesia (TH), motor function test (MFT) score and motor nerve conduction velocity (MNCV) were recorded. RESULTS: IND01 offered sustained protection against TH and deranged MFT scores in both models from 7-day onwards. Fifteen days of daily oral administration of IND01 restored MNCV reduction in rats with SNCI but not with PSNL. CONCLUSIONS: IND01 was found to be effective in rat models of painful peripheral neuropathy.
OBJECTIVE: To evaluate the effects of the standardized extract of fenugreek (Trigonella foenum-graecum L. Family: Leguminasae) seed (IND01) in animal models of peripheral neuropathy. METHODS:IND01 was prepared from fenugreek seeds and standardized by high performance liquid chromatography to a marker compound, trigonelline. The effects of daily oral administration of IND01 (50, 100 and 200 mg/kg) were studied in rats after partial sciatic nerve ligation (PSNL) and sciatic nerve crush injury (SNCI) during 30-days period. The measurements on thermal hyperalgesia (TH), motor function test (MFT) score and motor nerve conduction velocity (MNCV) were recorded. RESULTS:IND01 offered sustained protection against TH and deranged MFT scores in both models from 7-day onwards. Fifteen days of daily oral administration of IND01 restored MNCV reduction in rats with SNCI but not with PSNL. CONCLUSIONS:IND01 was found to be effective in rat models of painful peripheral neuropathy.
Authors: Heitor G Araújo-Filho; Lucindo J Quintans-Júnior; André S Barreto; Jackson R G S Almeida; Rosana S S Barreto; Jullyana S S Quintans Journal: Neurochem Res Date: 2015-12-08 Impact factor: 3.996
Authors: Yousef A Bin Jardan; Abdul Ahad; Mohammad Raish; Mohd Aftab Alam; Abdullah M Al-Mohizea; Fahad I Al-Jenoobi Journal: Pharm Biol Date: 2021-12 Impact factor: 3.503