Literature DB >> 22546002

Pluronic F108 coating decreases the lung fibrosis potential of multiwall carbon nanotubes by reducing lysosomal injury.

Xiang Wang1, Tian Xia, Matthew C Duch, Zhaoxia Ji, Haiyuan Zhang, Ruibin Li, Bingbing Sun, Sijie Lin, Huan Meng, Yu-Pei Liao, Meiying Wang, Tze-Bin Song, Yang Yang, Mark C Hersam, André E Nel.   

Abstract

We compared the use of bovine serum albumin (BSA) and pluronic F108 (PF108) as dispersants for multiwalled carbon nanotubes (MWCNTs) in terms of tube stability as well as profibrogenic effects in vitro and in vivo. While BSA-dispersed tubes were a potent inducer of pulmonary fibrosis, PF108 coating protected the tubes from damaging the lysosomal membrane and initiating a sequence of cooperative cellular events that play a role in the pathogenesis of pulmonary fibrosis. Our results suggest that PF108 coating could serve as a safer design approach for MWCNTs.

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Year:  2012        PMID: 22546002      PMCID: PMC4143198          DOI: 10.1021/nl300895y

Source DB:  PubMed          Journal:  Nano Lett        ISSN: 1530-6984            Impact factor:   11.189


  43 in total

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Authors:  James C Bonner
Journal:  Cytokine Growth Factor Rev       Date:  2004-08       Impact factor: 7.638

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Authors:  K C Stone; R R Mercer; P Gehr; B Stockstill; J D Crapo
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3.  Carbon Nanotubes in Biology and Medicine: In vitro and in vivo Detection, Imaging and Drug Delivery.

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4.  Length-dependent retention of carbon nanotubes in the pleural space of mice initiates sustained inflammation and progressive fibrosis on the parietal pleura.

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6.  Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation.

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Authors:  Ken Donaldson; Fiona A Murphy; Rodger Duffin; Craig A Poland
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8.  Mesenchymal cell survival in airway and interstitial pulmonary fibrosis.

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9.  Mouse pulmonary dose- and time course-responses induced by exposure to multi-walled carbon nanotubes.

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Journal:  Nat Nanotechnol       Date:  2009-10-25       Impact factor: 39.213

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  59 in total

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Authors:  Timur O Khaliullin; Elena R Kisin; Naveena Yanamala; Supraja Guppi; Martin Harper; Taekhee Lee; Anna A Shvedova
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2.  Use of a pro-fibrogenic mechanism-based predictive toxicological approach for tiered testing and decision analysis of carbonaceous nanomaterials.

Authors:  Xiang Wang; Matthew C Duch; Nikhita Mansukhani; Zhaoxia Ji; Yu-Pei Liao; Meiying Wang; Haiyuan Zhang; Bingbing Sun; Chong Hyun Chang; Ruibin Li; Sijie Lin; Huan Meng; Tian Xia; Mark C Hersam; André E Nel
Journal:  ACS Nano       Date:  2015-02-18       Impact factor: 15.881

3.  Effect of multi-walled carbon nanotube surface modification on bioactivity in the C57BL/6 mouse model.

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6.  Nanomechanical mechanism for lipid bilayer damage induced by carbon nanotubes confined in intracellular vesicles.

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Review 7.  Review of techniques and studies characterizing the release of carbon nanotubes from nanocomposites: Implications for exposure and human health risk assessment.

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Review 8.  Current approaches for safer design of engineered nanomaterials.

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Journal:  Ecotoxicol Environ Saf       Date:  2018-09-28       Impact factor: 6.291

9.  Genetic susceptibility to toxicologic lung responses among inbred mouse strains following exposure to carbon nanotubes and profiling of underlying gene networks.

Authors:  Evan A Frank; Vinicius S Carreira; Kumar Shanmukhappa; Mario Medvedovic; Daniel R Prows; Jagjit S Yadav
Journal:  Toxicol Appl Pharmacol       Date:  2017-04-19       Impact factor: 4.219

10.  Toxicological Profiling of Metal Oxide Nanoparticles in Liver Context Reveals Pyroptosis in Kupffer Cells and Macrophages versus Apoptosis in Hepatocytes.

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Journal:  ACS Nano       Date:  2018-03-19       Impact factor: 15.881

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