| Literature DB >> 22546002 |
Xiang Wang1, Tian Xia, Matthew C Duch, Zhaoxia Ji, Haiyuan Zhang, Ruibin Li, Bingbing Sun, Sijie Lin, Huan Meng, Yu-Pei Liao, Meiying Wang, Tze-Bin Song, Yang Yang, Mark C Hersam, André E Nel.
Abstract
We compared the use of bovine serum albumin (BSA) and pluronic F108 (PF108) as dispersants for multiwalled carbon nanotubes (MWCNTs) in terms of tube stability as well as profibrogenic effects in vitro and in vivo. While BSA-dispersed tubes were a potent inducer of pulmonary fibrosis, PF108 coating protected the tubes from damaging the lysosomal membrane and initiating a sequence of cooperative cellular events that play a role in the pathogenesis of pulmonary fibrosis. Our results suggest that PF108 coating could serve as a safer design approach for MWCNTs.Entities:
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Year: 2012 PMID: 22546002 PMCID: PMC4143198 DOI: 10.1021/nl300895y
Source DB: PubMed Journal: Nano Lett ISSN: 1530-6984 Impact factor: 11.189