OBJECTIVES: Aortic stenosis (AS) and atherosclerosis share similarities when it comes to risk factors and disease progression. Like in other heart diseases, we hypothesized that biomarkers like high-sensitive troponin T (hsTnT), N-terminal-pro-brain-natriuretic-peptide (NT-proBNP) and high-sensitive C-reactive protein (hsCRP) could be useful in risk stratification. DESIGN: A total of 136 patients (57% men, mean age 74 years), referred for evaluation of AS (valve area 0.62 cm(2), left ventricular ejection fraction 64%) were consecutively enrolled in the study. The relationship between hsTnT, hsCRP and NT-proBNP, different echocardiographic parameters of AS and cardiac function were investigated as well as their relation to all-cause mortality. RESULTS: In contrast to hsCRP, hsTnT and NT-proBNP were individually correlated with prognosis. Regression analysis identified diabetes and the combination of hsTnT and NT-proBNP as significant predictors of all-cause mortality. When analyzing patients without surgery separately, only the combination of hsTnT and NT-proBNP were identified as a significant predictor of all-cause mortality in multivariable analysis. CONCLUSION: The combination of NT-proBNP and hsTnT came out as the strongest predictor of outcome irrespective of surgical treatment or not and could be of particular interest in risk-stratification in AS-patients. The results should be confirmed in prospective studies both in symptomatic and asymptomatic patients.
OBJECTIVES:Aortic stenosis (AS) and atherosclerosis share similarities when it comes to risk factors and disease progression. Like in other heart diseases, we hypothesized that biomarkers like high-sensitive troponin T (hsTnT), N-terminal-pro-brain-natriuretic-peptide (NT-proBNP) and high-sensitive C-reactive protein (hsCRP) could be useful in risk stratification. DESIGN: A total of 136 patients (57% men, mean age 74 years), referred for evaluation of AS (valve area 0.62 cm(2), left ventricular ejection fraction 64%) were consecutively enrolled in the study. The relationship between hsTnT, hsCRP and NT-proBNP, different echocardiographic parameters of AS and cardiac function were investigated as well as their relation to all-cause mortality. RESULTS: In contrast to hsCRP, hsTnT and NT-proBNP were individually correlated with prognosis. Regression analysis identified diabetes and the combination of hsTnT and NT-proBNP as significant predictors of all-cause mortality. When analyzing patients without surgery separately, only the combination of hsTnT and NT-proBNP were identified as a significant predictor of all-cause mortality in multivariable analysis. CONCLUSION: The combination of NT-proBNP and hsTnT came out as the strongest predictor of outcome irrespective of surgical treatment or not and could be of particular interest in risk-stratification in AS-patients. The results should be confirmed in prospective studies both in symptomatic and asymptomatic patients.
Authors: Adam Blyme; Camilla Asferg; Olav W Nielsen; Thomas Sehestedt; Y Antero Kesäniemi; Christa Gohlke-Bärwolf; Kurt Boman; Ronnie Willenheimer; Simon Ray; Christoph A Nienaber; Anne Rossebø; Kristian Wachtell; Michael H Olsen Journal: Open Heart Date: 2015-02-04
Authors: Laura Mourino-Alvarez; Tatiana Martin-Rojas; Cecilia Corros-Vicente; Nerea Corbacho-Alonso; Luis R Padial; Jorge Solis; María G Barderas Journal: J Clin Med Date: 2020-07-28 Impact factor: 4.241
Authors: Anders Holmgren; Johan Ljungberg; Johan Hultdin; Bengt Johansson; Ingvar A Bergdahl; Ulf Näslund; Stefan Söderberg Journal: Open Heart Date: 2020-10
Authors: Hatim Seoudy; Moritz Lambers; Vincent Winkler; Linnea Dudlik; Sandra Freitag-Wolf; Johanne Frank; Christian Kuhn; Ashraf Yusuf Rangrez; Thomas Puehler; Georg Lutter; Peter Bramlage; Norbert Frey; Derk Frank Journal: Clin Res Cardiol Date: 2020-10-24 Impact factor: 5.460