Literature DB >> 22544982

Diversity Oriented Synthesis: Concise Entry to Novel Derivatives of Yohimbine and Corynanthe Alkaloids.

Zhiqian Wang1, Kyosuke Kaneda, Zhenglai Fang, Stephen F Martin.   

Abstract

A novel MCAP-cycloaddition sequence has been applied to the facile synthesis of β-carboline intermediates to gain rapid access to novel derivatives of yohimbine-like and corynanthe-like compounds that may be easily diversified by cross-coupling reactions and N-derivatizations to generate small compound libraries.

Entities:  

Year:  2011        PMID： 22544982      PMCID： PMC3335433          DOI： 10.1016/j.tetlet.2011.10.115

Source DB:  PubMed          Journal:  Tetrahedron Lett        ISSN： 0040-4039            Impact factor:   2.415


  12 in total

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2.  Facile and unified approach to skeletally diverse, privileged scaffolds.

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3.  Multicomponent assembly strategies for the synthesis of diverse tetrahydroisoquinoline scaffolds.

Authors:  Brett A Granger; Kyosuke Kaneda; Stephen F Martin
Journal:  Org Lett       Date:  2011-08-11       Impact factor: 6.005

4.  Charting biologically relevant chemical space: a structural classification of natural products (SCONP).

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5.  Synthesis of Diverse Heterocyclic Scaffolds via Tandem Additions to Imine Derivatives and Ring-Forming Reactions.

Authors:  James D Sunderhaus; Chris Dockendorff; Stephen F Martin
Journal:  Tetrahedron       Date:  2009-09-15       Impact factor: 2.457

6.  Structure-affinity relationships of 12-sulfonyl derivatives of 5,8,8a,9,10,11,12,12a,13,13a-decahydro-6H-isoquino[2,1-g][1 ,6] naphthyridines at alpha-adrenoceptors.

Authors:  R D Clark; D B Repke; J Berger; J T Nelson; A T Kilpatrick; C M Brown; A C MacKinnon; R U Clague; M Spedding
Journal:  J Med Chem       Date:  1991-02       Impact factor: 7.446

7.  Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes.

Authors:  Anders H Rosengren; Ramunas Jokubka; Damon Tojjar; Charlotte Granhall; Ola Hansson; Dai-Qing Li; Vini Nagaraj; Thomas M Reinbothe; Jonatan Tuncel; Lena Eliasson; Leif Groop; Patrik Rorsman; Albert Salehi; Valeriya Lyssenko; Holger Luthman; Erik Renström
Journal:  Science       Date:  2009-11-19       Impact factor: 47.728

8.  Synthesis and antihypertensive activity of 2-benzamido-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizines.

Authors:  S S Klioze; F J Ehrgott; J C Wilker; D L Woodward
Journal:  J Med Chem       Date:  1979-12       Impact factor: 7.446

9.  Applications of multicomponent reactions to the synthesis of diverse heterocyclic scaffolds.

Authors:  James D Sunderhaus; Stephen F Martin
Journal:  Chemistry       Date:  2009       Impact factor: 5.236

10.  Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation.

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  6 in total

1.  Natural Products and Their Mimics as Targets of Opportunity for Discovery.

Authors:  Stephen F Martin
Journal:  J Org Chem       Date:  2017-09-15       Impact factor: 4.354

2.  Multicomponent, Mannich-type assembly process for generating novel, biologically-active 2-arylpiperidines and derivatives.

Authors:  Simon Hardy; Stephen F Martin
Journal:  Tetrahedron       Date:  2014-10-07       Impact factor: 2.457

Review 3.  Evolution of a strategy for preparing bioactive small molecules by sequential multicomponent assembly processes, cyclizations, and diversification.

Authors:  James J Sahn; Brett A Granger; Stephen F Martin
Journal:  Org Biomol Chem       Date:  2014-08-19       Impact factor: 3.876

4.  Applications of Ring Closing Metathesis. Total Synthesis of (±)-Pseudotabersonine.

Authors:  Bo Cheng; James D Sunderhaus; Stephen F Martin
Journal:  Tetrahedron       Date:  2015-09-30       Impact factor: 2.457

5.  Multicomponent assembly processes for the synthesis of diverse yohimbine and corynanthe alkaloid analogues.

Authors:  Brett A Granger; Zhiqian Wang; Kyosuke Kaneda; Zhenglai Fang; Stephen F Martin
Journal:  ACS Comb Sci       Date:  2013-06-04       Impact factor: 3.784

6.  Design, Synthesis, and Evaluation of Novel Anti-Trypanosomal Compounds.

Authors:  Lance T Lepovitz; Alan R Meis; Sarah M Thomas; Justin Wiedeman; Alexandra Pham; Kojo Mensa-Wilmot; Stephen F Martin
Journal:  Tetrahedron       Date:  2020-03-03       Impact factor: 2.457
  6 in total

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