Literature DB >> 22544763

Human adipose-derived stem cells for the treatment of intracerebral hemorrhage in rats via femoral intravenous injection.

Kuo-Liang Yang1, Jiunn-Tat Lee, Cheng-Yoong Pang, Ting-Yi Lee, Shee-Ping Chen, Hock-Kean Liew, Shin-Yuan Chen, Tzu-Yung Chen, Py-Yu Lin.   

Abstract

Human adipose-derived stem cells (huADSC) were generated from fat tissue of a 65-year-old male donor. Flow cytometry and reverse transcription polymerase chain reaction (RT-PCR) analyses indicated that the huADSC express neural cell proteins (MAP2, GFAP, nestin and β-III tubulin), neurotrophic growth factors (BDNF and GDNF), and the chemotactic factor CXCR4 and its corresponding ligand CXCL12. In addition, huADSC expressed the characteristic mesenchymal stem cell (MSC) markers CD29, CD44, CD73, CD90, CD105 and HLA class I. The huADSC were employed, via a right femoral vein injection, to treat rats inflicted with experimental intracerebral hemorrhage (ICH). Behavioral measurement on the experimental animals, seven days after the huADSC therapy, showed a significant functional improvement in the rats with stem cell therapy in comparison with rats of the control group without the stem cell therapy. The injected huADSC were detectable in the brains of the huADSC treated rats as determined by histochemistry analysis, suggesting a role of the infused huADSC in facilitating functional recovery of the experimental animals with ICH induced stroke.

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Year:  2012        PMID： 22544763      PMCID： PMC6275678          DOI： 10.2478/s11658-012-0016-5

Source DB:  PubMed          Journal:  Cell Mol Biol Lett        ISSN： 1425-8153            Impact factor:   5.787


Supplementary material, approximately 1 MB.
  38 in total

1.  Surface markers expressed by multipotent human and mouse neural progenitor cells include tetraspanins and non-protein epitopes.

Authors:  H Klassen; M R Schwartz; A H Bailey; M J Young
Journal:  Neurosci Lett       Date:  2001-10-26       Impact factor: 3.046

Review 2.  Mechanisms of brain injury after intracerebral haemorrhage.

Authors:  Guohua Xi; Richard F Keep; Julian T Hoff
Journal:  Lancet Neurol       Date:  2006-01       Impact factor: 44.182

3.  Human adipose tissue is a source of multipotent stem cells.

Authors:  Patricia A Zuk; Min Zhu; Peter Ashjian; Daniel A De Ugarte; Jerry I Huang; Hiroshi Mizuno; Zeni C Alfonso; John K Fraser; Prosper Benhaim; Marc H Hedrick
Journal:  Mol Biol Cell       Date:  2002-12       Impact factor: 4.138

4.  Acute inflammatory reaction following experimental intracerebral hemorrhage in rat.

Authors:  C Gong; J T Hoff; R F Keep
Journal:  Brain Res       Date:  2000-07-14       Impact factor: 3.252

5.  Adipose tissue engineering by human adipose-derived stromal cells.

Authors:  Liu Hong; Ioana A Peptan; Aylin Colpan; Joseph L Daw
Journal:  Cells Tissues Organs       Date:  2006       Impact factor: 2.481

6.  Novel autologous cell therapy in ischemic limb disease through growth factor secretion by cultured adipose tissue-derived stromal cells.

Authors:  Hironori Nakagami; Kazuhisa Maeda; Ryuichi Morishita; Sota Iguchi; Tomoyuki Nishikawa; Yoichi Takami; Yasushi Kikuchi; Yukihiro Saito; Katsuto Tamai; Toshio Ogihara; Yasufumi Kaneda
Journal:  Arterioscler Thromb Vasc Biol       Date:  2005-10-13       Impact factor: 8.311

7.  Improvement of neurological deficits by intracerebral transplantation of human adipose tissue-derived stromal cells after cerebral ischemia in rats.

Authors:  Soo Kyung Kang; Dong Hyung Lee; Yong Chan Bae; Hae Kyu Kim; Sun Yong Baik; Jin Sup Jung
Journal:  Exp Neurol       Date:  2003-10       Impact factor: 5.330

8.  Systemic transplantation of human adipose stem cells attenuated cerebral inflammation and degeneration in a hemorrhagic stroke model.

Authors:  Jeong-Min Kim; Soon-Tae Lee; Kon Chu; Keun-Hwa Jung; Eun-Cheol Song; Se-Jeong Kim; Dong-In Sinn; Jin-Hee Kim; Dong-Kyu Park; Kyung-Mook Kang; Nan Hyung Hong; Hee-Kwon Park; Chong-Hyun Won; Kyu-Han Kim; Manho Kim; Sang Kun Lee; Jae-Kyu Roh
Journal:  Brain Res       Date:  2007-09-14       Impact factor: 3.252

9.  Electrophysiological properties of human adipose tissue-derived stem cells.

Authors:  Xiaowen Bai; Junyi Ma; Zhizhong Pan; Yao-Hua Song; Susanne Freyberg; Yasheng Yan; Daynene Vykoukal; Eckhard Alt
Journal:  Am J Physiol Cell Physiol       Date:  2007-08-08       Impact factor: 4.249

Review 10.  Stem cells from adipose tissue.

Authors:  Malgorzata Witkowska-Zimny; Katarzyna Walenko
Journal:  Cell Mol Biol Lett       Date:  2011-03-09       Impact factor: 5.787
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  13 in total

Review 1.  Concise review: adult mesenchymal stem cells, adult neural crest stem cells, and therapy of neurological pathologies: a state of play.

Authors:  Virginie Neirinckx; Cécile Coste; Bernard Rogister; Sabine Wislet-Gendebien
Journal:  Stem Cells Transl Med       Date:  2013-03-13       Impact factor: 6.940

Review 2.  Human-induced pluripotent stem cells derived hematopoietic progenitor cells for treatment of hematopoietic failure among trauma hemorrhagic shock patients.

Authors:  Manoj Kumar; Sanjeev Bhoi; Keshava Sharma
Journal:  J Clin Orthop Trauma       Date:  2018-04-22

Review 3.  Stem cell therapy in intracerebral hemorrhage rat model.

Authors:  Marcos F Cordeiro; Ana P Horn
Journal:  World J Stem Cells       Date:  2015-04-26       Impact factor: 5.326

4.  Neuronal differentiation of adipose-derived stem cells and their transplantation for cerebral ischemia.

Authors:  Guoping Tian; Jin Zhou; Jing'e Wang; Bing Xu; Li Li; Feng Zhu; Jian Han; Jianping Li; Siyang Zhang; Xiaoguang Luo
Journal:  Neural Regen Res       Date:  2012-09-05       Impact factor: 5.135

5.  GDNF secreted from adipose-derived stem cells stimulates VEGF-independent angiogenesis.

Authors:  Zhaohui Zhong; Huiying Gu; Jirun Peng; Wenzheng Wang; Brian H Johnstone; Keith L March; Martin R Farlow; Yansheng Du
Journal:  Oncotarget       Date:  2016-06-14

6.  Phase I/II randomized controlled trial of autologous bone marrow-derived mesenchymal stem cell therapy for chronic stroke.

Authors:  Kam Sze Tsang; Chi Ping Stephanie Ng; Xian Lun Zhu; George Kwok Chu Wong; Gang Lu; Anil Tejbhan Ahuja; Ka Sing Lawrence Wong; Ho Keung Ng; Wai Sang Poon
Journal:  World J Stem Cells       Date:  2017-08-26       Impact factor: 5.326

Review 7.  Current Perspectives regarding Stem Cell-Based Therapy for Alzheimer's Disease.

Authors:  Kyeong-Ah Kwak; Seung-Pyo Lee; Jin-Young Yang; Young-Seok Park
Journal:  Stem Cells Int       Date:  2018-03-01       Impact factor: 5.443

Review 8.  Stem Cell Therapy: A Promising Therapeutic Method for Intracerebral Hemorrhage.

Authors:  Liansheng Gao; Weilin Xu; Tao Li; Jingyin Chen; Anwen Shao; Feng Yan; Gao Chen
Journal:  Cell Transplant       Date:  2018-06-05       Impact factor: 4.064

9.  Are They Really Stem Cells? Scrutinizing the Identity of Cells and the Quality of Reporting in the Use of Adipose Tissue-Derived Stem Cells.

Authors:  Ernesto Balolong; Soojung Lee; Judee Grace Nemeno; Jeong Ik Lee
Journal:  Stem Cells Int       Date:  2015-12-20       Impact factor: 5.443

10.  Intravenous Administration of Bone Marrow-Derived Mesenchymal Stem Cell, but not Adipose Tissue-Derived Stem Cell, Ameliorated the Neonatal Hypoxic-Ischemic Brain Injury by Changing Cerebral Inflammatory State in Rat.

Authors:  Yuichiro Sugiyama; Yoshiaki Sato; Yuma Kitase; Toshihiko Suzuki; Taiki Kondo; Alkisti Mikrogeorgiou; Asuka Horinouchi; Shoichi Maruyama; Yoshie Shimoyama; Masahiro Tsuji; Satoshi Suzuki; Tokunori Yamamoto; Masahiro Hayakawa
Journal:  Front Neurol       Date:  2018-09-11       Impact factor: 4.003
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