BACKGROUND: The purpose of this study was to analyze the outcomes and treatment in patients with squamous cell carcinoma (SCC) of the oral tongue, as well as validate previously reported predictors of survival. METHODS: We retrospectively reviewed 259 patients treated with curative intent between 1994 and 2004. Kaplan-Meier estimates, log-rank test, and Cox regression models were used for statistical analysis. RESULTS: Two hundred fifty-nine patients were managed with surgery; 67 patients (25%) received adjuvant radiotherapy. Mean follow-up was 60 months. The 5-year local and regional control rates were 78% and 69.4%, respectively. The 5-year overall, disease-specific, and recurrence-free survival rates were 69%, 70.9%, and 53%, respectively. The only significant predictor of both overall survival (OS) and disease-free survival (DFS) on multivariable analysis was pathologic N classification. CONCLUSION: Treatment of early tongue SCC effectively achieves local control and DFS. Nodal disease remains to be 1 of the most important prognostic factors in terms of recurrence and survival.
BACKGROUND: The purpose of this study was to analyze the outcomes and treatment in patients with squamous cell carcinoma (SCC) of the oral tongue, as well as validate previously reported predictors of survival. METHODS: We retrospectively reviewed 259 patients treated with curative intent between 1994 and 2004. Kaplan-Meier estimates, log-rank test, and Cox regression models were used for statistical analysis. RESULTS: Two hundred fifty-nine patients were managed with surgery; 67 patients (25%) received adjuvant radiotherapy. Mean follow-up was 60 months. The 5-year local and regional control rates were 78% and 69.4%, respectively. The 5-year overall, disease-specific, and recurrence-free survival rates were 69%, 70.9%, and 53%, respectively. The only significant predictor of both overall survival (OS) and disease-free survival (DFS) on multivariable analysis was pathologic N classification. CONCLUSION: Treatment of early tongue SCC effectively achieves local control and DFS. Nodal disease remains to be 1 of the most important prognostic factors in terms of recurrence and survival.
Authors: Thaís Bianca Brandão; Karina Morais-Faria; Ana Carolina Prado Ribeiro; César Rivera; João Victor Salvajoli; Marcio Ajudarte Lopes; Joel B Epstein; Praveen R Arany; Gilberto de Castro; Cesar Augusto Migliorati; Alan Roger Santos-Silva Journal: Support Care Cancer Date: 2018-02-08 Impact factor: 3.603
Authors: Richard J Cassidy; Jeffrey M Switchenko; Naresh Jegadeesh; Mutlay Sayan; Matthew J Ferris; Bree R Eaton; Kristin A Higgins; Jeffrey T Wadsworth; Kelly R Magliocca; Nabil F Saba; Jonathan J Beitler Journal: JAMA Otolaryngol Head Neck Surg Date: 2017-04-01 Impact factor: 6.223
Authors: G Tirelli; S Zacchigna; F Boscolo Nata; E Quatela; R Di Lenarda; M Piovesana Journal: Eur Arch Otorhinolaryngol Date: 2016-08-04 Impact factor: 2.503
Authors: Parul Sinha; Trevor Hackman; Brian Nussenbaum; Ningying Wu; James S Lewis; Bruce H Haughey Journal: Head Neck Date: 2013-06-01 Impact factor: 3.147
Authors: Annette M Lim; Nicholas C Wong; Ruth Pidsley; Elena Zotenko; June Corry; Alexander Dobrovic; Susan J Clark; Danny Rischin; Benjamin Solomon Journal: Clin Epigenetics Date: 2016-07-18 Impact factor: 6.551