BACKGROUND: Prior studies have reported an association between traffic-related air pollution in urban areas and exacerbation of cardiovascular disease. We assess here whether time spent in different modes of transportation can trigger the onset of acute myocardial infarction (AMI). DESIGN: We performed a case-crossover study. We interviewed consecutive cases of AMI in the KORA Myocardial Infarction Registry in Augsburg, Southern Germany between February 1999 and December 2003 eliciting data on potential triggers in the four days preceding myocardial infarction onset. RESULTS: A total of 1459 cases with known date and time of AMI symptom onset, who had survived 24 hours after the onset, completed the registry's standard interview on potential triggers of AMI. An association between exposure to traffic and AMI onset 1 hour later was observed (odds ratio: 3.2; 95% confidence interval [CI]: 2.7-3.9, p < 0.001). Using a car was the most common source of traffic exposure; nevertheless, times spent in public transport or on a bicycle were similarly associated with AMI onset 1 hour later. While the highest risk for AMI onset was within 1 hour of exposure to traffic, the elevated risk persisted for up to 6 hours. Women, patients aged 65 years or older, patients not part of the workforce, and those with a history of angina or diabetes exhibited the largest associations between times spent in traffic and AMI onset 1 hour later. CONCLUSION: The data suggest that transient exposure to traffic regardless of the means of transportation may increase the risk of AMI transiently.
BACKGROUND: Prior studies have reported an association between traffic-related air pollution in urban areas and exacerbation of cardiovascular disease. We assess here whether time spent in different modes of transportation can trigger the onset of acute myocardial infarction (AMI). DESIGN: We performed a case-crossover study. We interviewed consecutive cases of AMI in the KORA Myocardial Infarction Registry in Augsburg, Southern Germany between February 1999 and December 2003 eliciting data on potential triggers in the four days preceding myocardial infarction onset. RESULTS: A total of 1459 cases with known date and time of AMI symptom onset, who had survived 24 hours after the onset, completed the registry's standard interview on potential triggers of AMI. An association between exposure to traffic and AMI onset 1 hour later was observed (odds ratio: 3.2; 95% confidence interval [CI]: 2.7-3.9, p < 0.001). Using a car was the most common source of traffic exposure; nevertheless, times spent in public transport or on a bicycle were similarly associated with AMI onset 1 hour later. While the highest risk for AMI onset was within 1 hour of exposure to traffic, the elevated risk persisted for up to 6 hours. Women, patients aged 65 years or older, patients not part of the workforce, and those with a history of angina or diabetes exhibited the largest associations between times spent in traffic and AMI onset 1 hour later. CONCLUSION: The data suggest that transient exposure to traffic regardless of the means of transportation may increase the risk of AMI transiently.
Authors: David E Newby; Pier M Mannucci; Grethe S Tell; Andrea A Baccarelli; Robert D Brook; Ken Donaldson; Francesco Forastiere; Massimo Franchini; Oscar H Franco; Ian Graham; Gerard Hoek; Barbara Hoffmann; Marc F Hoylaerts; Nino Künzli; Nicholas Mills; Juha Pekkanen; Annette Peters; Massimo F Piepoli; Sanjay Rajagopalan; Robert F Storey Journal: Eur Heart J Date: 2014-12-09 Impact factor: 29.983
Authors: Masako Morishita; Lu Wang; Kelly Speth; Nina Zhou; Robert L Bard; Fengyao Li; Jeffrey R Brook; Sanjay Rajagopalan; Robert D Brook Journal: Am J Hypertens Date: 2019-10-16 Impact factor: 2.689
Authors: Sampada K Gandhi; David Q Rich; Pamela A Ohman-Strickland; Howard M Kipen; Andrew Gow Journal: Inhal Toxicol Date: 2014-06 Impact factor: 2.724
Authors: Allison P Patton; Robert Laumbach; Pamela Ohman-Strickland; Kathy Black; Shahnaz Alimokhtari; Paul Lioy; Howard M Kipen Journal: Atmos Environ (1994) Date: 2016-08-12 Impact factor: 4.798
Authors: Gudrun Weinmayr; Frauke Hennig; Kateryna Fuks; Michael Nonnemacher; Hermann Jakobs; Stefan Möhlenkamp; Raimund Erbel; Karl-Heinz Jöckel; Barbara Hoffmann; Susanne Moebus Journal: Environ Health Date: 2015-06-19 Impact factor: 5.984
Authors: Andrea Hricko; Glovioell Rowland; Sandrah Eckel; Angelo Logan; Maryam Taher; John Wilson Journal: Int J Environ Res Public Health Date: 2014-02-10 Impact factor: 3.390